Since its discovery as a biologically active molecule in the late 1980s, nitric oxide (NO) has
been found to play an important role as signal molecule in many parts of the organism as …

Over the past 5 years there has been an explosion of new information on the physiological
and pathophysiological roles of NO within the heart as in other organ systems. In this review …

Nitric oxide (NO) is a potent biologic mediator with diverse physiologic and pathophysiologic
roles. NO is produced from L-arginine by the family of nitric oxide synthase (NOS) enzymes …

Increased inducible nitric oxide synthase (iNOS) expression is a component of the immune
response and has been demonstrated in cardiomyocytes in septic shock, myocarditis …

Significance: The regulation of myocardial function by constitutive nitric oxide synthases
(NOS) is important for the maintenance of myocardial Ca2+ homeostasis, relaxation and …

Complex paracrine interactions exist between endothelial cells and cardiac myocytes in the
heart. Cardiac endothelial cells release (or metabolize) several diffusible agents (eg, nitric …

The different cell types comprising cardiac muscle express one or more of the three isoforms
(neuronal NOS, or nNOS; inducible NOS, or iNOS; and endothelial NOS, or eNOS) of nitric …

Recently, development of a caveolin-1-deficient (Cav-1 null) mouse model has allowed the
detailed analysis of caveolin-1's function in the context of a whole animal. Interestingly, we …

Increased production of nitric oxide (NO) after induction of the cytokine-inducible isoform of
nitric oxide synthase (iNOS or NOS2) in cardiac myocytes and other parenchymal cells …

Anthracycline antibiotics are potent antitumor agents whose activity is severely limited by a
cumulative dose‐dependent chronic cardiotoxicity that results from the summation of …