The discovery of bioactive natural products remains a time-consuming and challenging task.
The ability to link high-confidence metabolite annotations in crude extracts with activity …

Simple Summary Uveal melanoma is a deadly form of eye cancer with a high rate of
metastasis. Once metastasis occurs, patients are often left with a short survival time, since …

As an apple fruit rot disease related fungus, Alternaria spp. could bring severe hazardous
risk to apple fruits during postharvest storage. In this research, cold treatment is investigated …

The cyclodepsipeptide FR900359 (FR) and its analogs are able to selectively inhibit the
class of Gq proteins by blocking GDP/GTP exchange. The inhibitor binding site of Gq has …

Access to the cyclic depsipeptide FR900359 (FR), a selective Gq/11 protein inhibitor of high
pharmacological interest and a potential lead molecule for targeted therapy of cancers with …

The macrocyclic depsipeptides YM-254890 (YM) and FR900359 (FR) are natural products,
which inhibit heterotrimeric Gαq/11 proteins with high potency and outstanding selectivity …

The macrocyclic depsipeptides YM-254890 (YM) and FR900359 (FR) are potent inhibitors of
Gα q/11 proteins. They are important pharmacological tools and have potential as …

LC–MS/MS-based molecular networking annotation coupled 1H NMR detection allowed the
depiction of the soft coral Clavularia viridis to produce a profile of dolabellane-type …

The cyclic depsipeptide FR900359: An insecticide with a novel mode of action from Cand.
Burkholderia crenata and Chromobacterium vaccinii Secondary metabolites (SM) are known …

The natural macrocyclic depsipeptides YM-254890 (YM) and FR900359 (FR), produced by
bacteria, are potent and selective inhibitors of Gαq/11 proteins. These compounds have …