Globally, colorectal cancer (CRC) is the third most commonly diagnosed malignancy and the
second leading cause of cancer death. Arising through three major pathways, including …

To a large extent, cancer conforms to evolutionary rules defined by the rates at which clones
mutate, adapt and grow. Next-generation sequencing has provided a snapshot of the …

Chromosomal instability (CIN) is a driver of cancer metastasis,,–, yet the extent to which this
effect depends on the immune system remains unknown. Using ContactTracing—a newly …

Chromosomal instability is a hallmark of cancer that results from ongoing errors in
chromosome segregation during mitosis. Although chromosomal instability is a major driver …

Human beings are made of~ 50 trillion cells which arise from serial mitotic divisions of a
single cell-the fertilised egg. Remarkably, the early human embryo is often chromosomally …

Chromosome segregation errors cause aneuploidy and genomic heterogeneity, which are
hallmarks of cancer in humans. A persistent high frequency of these errors (chromosomal …

Mitosis is a delicate event that must be executed with high fidelity to ensure genomic
stability. Recent work has provided insight into how mitotic errors shape cancer genomes by …

Colorectal cancer (CRC) is the third most frequently detected type of cancer, and the second
most common cause of cancer-related mortality globally. The American Cancer Society …

All eukaryotic cells prepare for cell division by forming a “mitotic spindle”—a bipolar machine
made from microtubules (MTs) and many associated proteins. This device organizes the …

Large-scale, massively parallel sequencing of human cancer samples has revealed
tremendous genetic heterogeneity within individual tumors. Indeed, tumors are composed of …