Abstract Purpose of Review Obesity is a heterogeneous condition, yet sex/gender is rarely
considered in the prevention or clinical care of this disease. This review examined and …

NAFLD/NASH is a sex‐dimorphic disease, with a general higher prevalence in men. Women
are at reduced risk of NAFLD compared to men in fertile age, whereas after menopause …

Background The long-term efficacy and safety of time-restricted eating for weight loss are not
clear. Methods We randomly assigned 139 patients with obesity to time-restricted eating …

Importance Obesity is the leading cause of obstructive sleep apnea (OSA); however, the
effects of weight loss and lifestyle interventions on OSA and comorbidities remain uncertain …

Obesity increases the risk of clinical decompensation in cirrhosis, possibly by increasing
portal pressure. Whether weight reduction can be safely achieved through lifestyle (LS) …

Aims The PREVIEW lifestyle intervention study (ClinicalTrials. gov Identifier: NCT01777893)
is, to date, the largest, multinational study concerning prevention of type‐2 diabetes. We …

Peroxisome proliferator-activated receptors (PPAR), ligand-activated transcription factors of
the nuclear hormone receptor superfamily, have been identified as key metabolic regulators …

Consistent epidemiological and clinical evidence strongly indicates that chronic
noncommunicable diseases are largely associated with four lifestyle risk factors …

Background Evidence of the effectiveness of treatment for obesity delivered in primary care
settings in underserved populations is lacking. Methods We conducted a cluster-randomized …

Background Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic
liver disease worldwide, with prevalence above 30% in many adult populations. Strongly …