[HTML][HTML] Insights into human cerebral white matter maturation and degeneration across the adult lifespan

M Kiely, C Triebswetter, LE Cortina, Z Gong… - Neuroimage, 2022 - Elsevier
White matter (WM) microstructural properties change across the adult lifespan and with
neuronal diseases. Understanding microstructural changes due to aging is paramount to …

C-NODDI: a constrained NODDI model for axonal density and orientation determinations in cerebral white matter

MH Alsameen, Z Gong, W Qian, M Kiely… - Frontiers in …, 2023 - frontiersin.org
Purpose Neurite orientation dispersion and density imaging (NODDI) provides measures of
neurite density and dispersion through computation of the neurite density index (NDI) and …

Hypertensive adults exhibit lower myelin content: a multicomponent relaxometry and diffusion magnetic resonance imaging study

JP Laporte, ME Faulkner, Z Gong, MABS Akhonda… - …, 2023 - Am Heart Assoc
BACKGROUND: It is unknown whether hypertension plays any role in cerebral myelination.
To fill this knowledge gap, we studied 90 cognitively unimpaired adults, age range 40 to 94 …

The effect of the human brainstem myelination on gait speed in normative aging

MABS Akhonda, ME Faulkner, Z Gong… - The Journals of …, 2023 - academic.oup.com
The brainstem functions as a relay and integrative brain center and plays an essential role in
motor function. Whether brainstem tissue deterioration, including demyelination, affects …

Aging pattern of the brainstem based on volumetric measurement and optimized surface shape analysis

M Hu, F Xu, S Liu, Y Yao, Q Xia, C Zhu, X Zhang… - Brain Imaging and …, 2024 - Springer
The brainstem, a small and crucial structure, is connected to the cerebrum, spinal cord, and
cerebellum, playing a vital role in regulating autonomic functions, transmitting motor and …

In vivo marker of brainstem myelin is associated to quantitative sleep parameters in healthy young men

P Talwar, M Deantoni, M Van Egroo, V Muto… - Scientific Reports, 2023 - nature.com
The regional integrity of brain subcortical structures has been implicated in sleep–wake
regulation, however, their associations with sleep parameters remain largely unexplored …

[PDF][PDF] Association of Plasma Markers of Alzheimer's Disease, Neurodegeneration, and Neuroinflammation with the Choroid Plexus Integrity in Aging

M Resnick, JM Egan - Aging and Disease, 2024 - researchgate.net
The choroid plexus (CP) is a vital brain structure essential for cerebrospinal fluid (CSF)
production. Moreover, alterations in the CP's structure and function are implicated in …

[HTML][HTML] REUSED: A deep neural network method for rapid whole-brain high-resolution myelin water fraction mapping from extremely under-sampled MRI

Z Gong, N Khattar, M Kiely, C Triebswetter… - … Medical Imaging and …, 2023 - Elsevier
Abstract Changes in myelination are a cardinal feature of brain development and the
pathophysiology of several central nervous system diseases, including multiple sclerosis …

Comparing neuromotor functions in 45-and 65-year-old adults with 18-year-old adolescents

TH Kakebeeke, A Chaouch, J Caflisch… - Frontiers in human …, 2023 - frontiersin.org
Aim This cross-sectional analysis investigates how neuromotor functions of two independent
cohorts of approximately 45-and 65-year-old individuals are different from 18-year-old …

Cerebral aggregate g-ratio mapping using magnetic resonance relaxometry and diffusion tensor imaging to investigate sex and age-related differences in white matter …

LE Cortina, RW Kim, M Kiely, C Triebswetter… - Magnetic resonance …, 2022 - Elsevier
Axonal demyelination is a cardinal feature of aging and age-related diseases. The g-ratio,
mathematically defined as the inner-to-outer diameter of a myelinated axon, is used as a …