Pharmacological significance of nitrogen-containing five and six-membered heterocyclic scaffolds as potent cholinesterase inhibitors for drug discovery
N-heterocycles are crucial due to their biological, chemical, and practical significance. They
are heavily investigated in biological processes involving anticancer, anti-inflammatory …
are heavily investigated in biological processes involving anticancer, anti-inflammatory …
Triazole derivatives as inhibitors of Alzheimer's disease: current developments and structure-activity relationships
M Xu, Y Peng, L Zhu, S Wang, J Ji… - European journal of …, 2019 - Elsevier
Alzheimer's disease (AD) is a well known neurodegenerative disorder alarming millions of
people worldwide and the subsequent epidemiological statistics highlights the implication of …
people worldwide and the subsequent epidemiological statistics highlights the implication of …
Discovery of sulfadrug–pyrrole conjugates as carbonic anhydrase and acetylcholinesterase inhibitors
Human carbonic anhydrase (hCA) isoenzymes are zinc ion‐containing, widespread
metalloenzymes and they classically play a role in pH homeostasis maintenance. CA …
metalloenzymes and they classically play a role in pH homeostasis maintenance. CA …
Isofraxidin: Antioxidant, Anti‐carbonic Anhydrase, Anti‐cholinesterase, Anti‐diabetic, and in Silico Properties
The development of innovative pharmacological formulations for the treatment and
prevention of various major diseases, including cancer, diabetes, and glaucoma, has been …
prevention of various major diseases, including cancer, diabetes, and glaucoma, has been …
Synthesis and bioactivities of pyrazoline benzensulfonamides as carbonic anhydrase and acetylcholinesterase inhibitors with low cytotoxicity
(3-Substitutedphenyl-5-polymethoxyphenyl-4, 5-dihydro-1H-pyrazol-1-yl)
benzenesulfonamides (9–16) were synthesized and their chemical structures were …
benzenesulfonamides (9–16) were synthesized and their chemical structures were …
Design and synthesis of heterocyclic azole based bioactive compounds: Molecular structures, quantum simulation, and mechanistic studies through docking as multi …
J Haribabu, V Garisetti, RE Malekshah… - Journal of molecular …, 2022 - Elsevier
Abstract Two heterocyclic azole compounds, 3-(2, 3-dihydrobenzo [d] thiazol-2-yl)-4H-
chromen-4-one (SVS1) and 5-(1H-indol-3-yl)-4-methyl-2, 4-dihydro-3H-1, 2, 4-triazole-3 …
chromen-4-one (SVS1) and 5-(1H-indol-3-yl)-4-methyl-2, 4-dihydro-3H-1, 2, 4-triazole-3 …
Design, synthesis, characterization, crystal structure, in silico studies, and inhibitory properties of the PEPPSI type Pd (II) NHC complexes bearing chloro/fluorobenzyl …
This work contains synthesis, characterization, crystal structure, and biological activity of a
new series of the PEPPSI type Pd (II) NHC complexes [(NHC) Pd (II)(3-Cl-py)]. NMR, FTIR …
new series of the PEPPSI type Pd (II) NHC complexes [(NHC) Pd (II)(3-Cl-py)]. NMR, FTIR …
Chemistry and biological activities of 1, 2, 4-triazolethiones—antiviral and anti-infective drugs
Mercapto-substituted 1, 2, 4-triazoles are very interesting compounds as they play an
important role in chemopreventive and chemotherapeutic effects on cancer. In recent …
important role in chemopreventive and chemotherapeutic effects on cancer. In recent …
Synthesis, characterization, biological evaluation, and in silico studies of novel 1, 3‐diaryltriazene‐substituted sulfathiazole derivatives
In the present study, a series of eleven novel 1, 3‐diaryltriazene‐substituted sulfathiazole
moieties (ST1–11) was synthesized by the reaction of diazonium salt of sulfathiazole with …
moieties (ST1–11) was synthesized by the reaction of diazonium salt of sulfathiazole with …
Coumarins: antifungal effectiveness and future therapeutic scope
The antifungals that are in current clinical practice have a high occurrence of a side effect
and multidrug resistance (MDR). Researchers across the globe are trying to develop a …
and multidrug resistance (MDR). Researchers across the globe are trying to develop a …