Cryo-electron microscopy (cryo-EM) of non-crystalline single particles is a biophysical
technique that can be used to determine the structure of biological macromolecules and …

Differential scanning fluorimetry (DSF) is an accessible, rapid, and economical biophysical
technique that has seen many applications over the years, ranging from protein folding state …

INTRODUCTION TP53 (tumor protein P53), a tumor suppressor gene, is the most commonly
mutated cancer-driver gene. Nevertheless, drugs that target mutant p53, the protein product …

The global health emergency generated by coronavirus disease 2019 (COVID-19) has
prompted the search for preventive and therapeutic treatments for its pathogen, the severe …

Baloxavir acid (BXA), derived from the prodrug baloxavir marboxil (BXM), potently and
selectively inhibits the cap-dependent endonuclease within the polymerase PA subunit of …

Thermal shift assays are used to study thermal stabilization of proteins upon ligand binding.
Such assays have been used extensively on purified proteins in the drug discovery industry …

Cryo-electron microscopy (cryo-EM) of single-particle specimens is used to determine the
structure of proteins and macromolecular complexes without the need for crystals. Recent …

Purification of recombinant proteins for biochemical assays and structural studies is time‐
consuming and presents inherent difficulties that depend on the optimization of protein …

Leukotrienes (LT) are lipid mediators of the inflammatory response that are linked to asthma
and atherosclerosis. LT biosynthesis is initiated by 5-lipoxygenase (5-LOX) with the …

Protein stability is a topic of major interest for the biotechnology, pharmaceutical and food
industries, in addition to being a daily consideration for academic researchers studying …