Glutathione (GSH) is an important member of cellular antioxidative system. In cancer cells, a
high level of GSH is indispensable to scavenge excessive reactive oxygen species (ROS) …

N-acetylcysteine (NAC), which is an acetylated cysteine compound, has aroused scientific
interest for decades due to its important medical applications. It also represents a nutritional …

Objective. To review the clinical usefulness of N‐acetylcysteine (NAC) as treatment or
adjunctive therapy in a number of medical conditions. Use in Tylenol overdose, cystic …

N-acetylcysteine (NAC) is a medicine widely used to treat paracetamol overdose and as a
mucolytic compound. It has a well-established safety profile, and its toxicity is uncommon …

Patients with inflammatory bowel disease (IBD) suffer from depression at higher rates than
the general population. An etiological trigger of depressive symptoms is theorised to be …

Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor encoded by NFE2L2.
Under oxidative stress, Nrf2 does not undergo its normal cytoplasmic degradation but …

N-acetylcysteine is the acetylated form of the amino acid L-cysteine and a precursor to
glutathione (GSH). It has been known for a long time as a powerful antioxidant and as an …

While the immune system is essential for survival, an excessive or prolonged inflammatory
response, such as that resulting from sustained heavy alcohol use, can damage the host …

Glutamate plays an important role in excitotoxicity and ferroptosis. Excitotoxicity occurs
through over-stimulation of glutamate receptors, specifically NMDAR, while in the non …

We provide a comprehensive update on mitochondrial medicine therapies based on current
evidence and our single-center clinical experience to support or refute their use, and provide …