Obesity remains the most important risk factor for the incidence and progression of
osteoarthritis (OA). The leading cause of OA was believed to be overloading the joints due to …

Intra-articular drug delivery has a number of advantages over systemic administration;
however, for the past 20 years, intra-articular treatment options for the management of knee …

Osteoarthritis (OA) and rheumatoid arthritis (RA) are chronic and progressive inflammatory
joint diseases that affect a large population worldwide. Intra-articular administration of …

Pain due to osteoarthritis (OA) is one of the most frequent causes of chronic pain. However,
the mechanisms of OA pain are poorly understood. This review addresses the mechanisms …

Osteoarthritis (OA) is the leading cause of function loss and disability among the elderly, with
significant burden on the individual and society. It is a severe disease for its high disability …

Osteoarthritis (OA) is the most common form of joint disease and a major cause of pain and
disability in the adult population. Interestingly, there are patients with symptomatic OA …

Highlights•Precision medicine is necessary to treat multiple facets of osteoarthritis.•Disease-
modifying osteoarthritis drugs (DMOADs) and drug delivery systems (DDSs) are …

Both epidemiologic and clinical research continues to be performed in osteoarthritis (OA).
While epidemiologic studies identify risk factors for incident and progressive disease, clinical …

Osteoarthritis (OA) is currently the most widespread musculoskeletal condition and primarily
affects weight-bearing joints such as the knees and hips. Importantly, knee OA remains a …

Osteoarthritis (OA) is a common degenerative disease that affects the vast majority of the
elderly and may eventually embark on the road of the total knee arthroplasty (TKA), although …