HP1 was first described in Drosophila as a heterochromatin-associated protein with dosage-
dependent effects on heterochromatin-induced gene silencing. Recently, membership of the …

The chromodomain is a highly conserved sequence motif that has been identified in a
variety of animal and plant species. In mammals, chromodomain proteins appear to be …

The Third Edition of Chromatin: Structure and Function brings the reader up-to-date with the
remarkable progress in chromatin research over the past three years. It has been …

We have immunolabeled human and mouse metaphase chromosomes with antibodies
specific for the acetylated isoforms of histone H4. All chromosomes were labeled in regions …

Live cell imaging is a powerful method to study protein dynamics at the cell surface, but
conventional imaging probes are bulky, or interfere with protein function,, or dissociate from …

The chromo and SET domains are conserved sequence motifs present in chromosomal
proteins that function in epigenetic control of gene expression, presumably by modulating …

At the nuclear envelope in higher eukaryotic cells, the nuclear lamina and the
heterochromatin are adjacent to the inner nuclear membrane, and their attachment is …

Nuclear receptors (NRs) are ligand‐inducible transcription factors that mediate complex
effects on development, differentiation and homeostasis. They regulate the transcription of …

The ura4+ gene displays phenotypes consistent with variegated expression when inserted
at 11 sites throughout fission yeast centromere 1. An abrupt transition occurs between the …

Krüppel-associated box (KRAB) domains are present in approximately one-third of all
human zinc finger proteins (ZFPs) and are potent transcriptional repression modules. We …