Constitutive heterochromatin, mainly formed at the gene-poor regions of pericentromeres, is
believed to ensure a condensed and transcriptionally inert chromatin conformation …

Heat shock factors (HSFs) are essential for all organisms to survive exposures to acute
stress. They are best known as inducible transcriptional regulators of genes encoding …

DNA hypomethylation was the initial epigenetic abnormality recognized in human tumors.
However, for several decades after its independent discovery by two laboratories in 1983, it …

Mammalian telomeres consist of non-coding TTAGGG repeats that are bound by the multi-
protein complex'shelterin', thus protecting chromosome ends from DNA repair mechanisms …

The premature aging disease Hutchinson–Gilford Progeria Syndrome (HGPS) is caused by
a mutant lamin A (LAΔ50). Nuclei in cells expressing LAΔ50 are abnormally shaped and …

Various stress factors leading to protein damage induce the activation of an evolutionarily
conserved cell protective mechanism, the heat shock response (HSR), to maintain protein …

It is clear now that eukaryotic cells contain numerous membrane-less organelles, many of
which are formed in response to changes in the cellular environment. Being typically liquid …

Cellular pathways are established and maintained by stochastic interactions of highly
mobile molecules. The nucleolus plays a central role in the regulation of these molecular …

We present an analysis of chromatin fiber structure across the human genome. Compact
and open chromatin fiber structures were separated by sucrose sedimentation and their …

Processing bodies (PBs) and Stress Granules (SGs) are the founding members of a new
class of RNA granules, known as mRNA silencing foci, as they harbour transcripts …