Focus on extracellular vesicles: physiological role and signalling properties of extracellular membrane vesicles

N Iraci, T Leonardi, F Gessler, B Vega… - International journal of …, 2016 - mdpi.com
Extracellular vesicles (EVs) are a heterogeneous population of secreted membrane
vesicles, with distinct biogenesis routes, biophysical properties and different functions both …

[HTML][HTML] The stem cell secretome and its role in brain repair

D Drago, C Cossetti, N Iraci, E Gaude, G Musco… - Biochimie, 2013 - Elsevier
Compelling evidence exists that non-haematopoietic stem cells, including mesenchymal
(MSCs) and neural/progenitor stem cells (NPCs), exert a substantial beneficial and …

The therapeutic potential of neural stem cells

G Martino, S Pluchino - Nature Reviews Neuroscience, 2006 - nature.com
Recent evidence shows that transplantation of neural stem/precursor cells may protect the
central nervous system from inflammatory damage through a'bystander'mechanism that is …

Cross-talk between neural stem cells and immune cells: the key to better brain repair?

Z Kokaia, G Martino, M Schwartz, O Lindvall - Nature neuroscience, 2012 - nature.com
Systemic or intracerebral delivery of neural stem and progenitor cells (NSPCs) and
activation of endogenous NSPCs hold much promise as potential treatments for diseases in …

Pathophysiology and therapy of experimental stroke

KA Hossmann - Cellular and molecular neurobiology, 2006 - Springer
1. Stroke is the neurological evidence of a critical reduction of cerebral blood flow in a
circumscribed part of the brain, resulting from the sudden or gradually progressing …

Stem cell‐based therapies for ischemic stroke

L Hao, Z Zou, H Tian, Y Zhang… - BioMed research …, 2014 - Wiley Online Library
In recent years, stem cell‐based approaches have attracted more attention from scientists
and clinicians due to their possible therapeutical effect on stroke. Animal studies have …

Anti-inflammatory mechanism of intravascular neural stem cell transplantation in haemorrhagic stroke

ST Lee, K Chu, KH Jung, SJ Kim, DH Kim, KM Kang… - Brain, 2008 - academic.oup.com
Neural stem cell (NSC) transplantation has been investigated as a means to reconstitute the
damaged brain after stroke. In this study, however, we investigated the effect on acute …

Neural stem cells transfected with reactive oxygen species–responsive polyplexes for effective treatment of ischemic stroke

XC Jiang, JJ Xiang, HH Wu, TY Zhang… - Advanced …, 2019 - Wiley Online Library
Neural stem cells (NSCs), capable of ischemia‐homing, regeneration, and differentiation,
exert strong therapeutic potentials in treating ischemic stroke, but the curative effect is limited …

Cell transplantation therapy for stroke

T Bliss, R Guzman, M Daadi, GK Steinberg - Stroke, 2007 - Am Heart Assoc
No treatment currently exists to restore lost neurological function after stroke. A growing
number of studies highlight the potential of stem cell transplantation as a novel therapeutic …

A conditionally immortal clonal stem cell line from human cortical neuroepithelium for the treatment of ischemic stroke

K Pollock, P Stroemer, S Patel, L Stevanato… - Experimental …, 2006 - Elsevier
Transplantation of neural stem cells into the brain is a novel approach to the treatment of
chronic stroke disability. For clinical application, safety and efficacy of defined, stable cell …