Bladder cancer—the tenth most frequent cancer worldwide—has a heterogeneous natural
history and clinical behaviour. The predominant histological subtype, urothelial bladder …

Prostatic hyperplasia (PH) is a common urologic disease that affects mostly elderly men. PH
can be classified as benign prostatic hyperplasia (BPH), or prostate cancer (PCa) based on …

Incidence of skeletal metastases and death from prostate cancer greatly increases with age
and obesity, conditions which increase marrow adiposity. Bone marrow adipocytes are …

Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear receptor
superfamily that regulate the expression of genes related to lipid and glucose metabolism …

Advanced and metastatic prostate cancer is often incurable, but its dependency on certain
molecular alterations may provide the basis for targeted therapies. A growing body of …

Stromal progenitors are found in many different tissues, where they play an important role in
the maintenance of tissue homeostasis owing to their ability to differentiate into parenchymal …

The tumor microenvironment is a complex and dynamic cellular community comprising the
tumor epithelium and various tumor-supporting cells such as immune cells, fibroblasts …

The nuclear receptor peroxisome-proliferation-activated receptor gamma (PPARγ), a
transcriptional master regulator of glucose and lipid metabolism, inhibits the growth of …

Increasing evidence suggests that tumor development requires not only oncogene/tumor
suppressor mutations to drive the growth, survival, and metastasis but also metabolic …

Triple Negative breast cancer (TNBC) is a subtype of breast cancer that lacks the expression
of estrogen receptor (ER), progesterone receptor, and human epidermal growth factor …