The mortality rate of liver cancer is gradually increasing worldwide due to the increasing risk
factors such as fatty liver, diabetes, and alcoholic cirrhosis. The diagnostic methods of liver …

Multivalent interactions are omnipresent in biology and confer biological systems with
dramatically enhanced affinities towards different receptors. Such multivalent binding …

The broadest clinical application of siRNA therapeutics will be facilitated by drug-loaded
delivery systems that maintain stability and potency for long times under ambient conditions …

Background/aims RNA interference (RNAi), a sequence-specific gene silencing technology
triggered by small interfering RNA (siRNA), represents promising new avenues for treatment …

In addition to general unavailability of specific antiviral therapeutics for a variety of viral
diseases, usage of most antiviral drugs is linked to their limited solubility in aqueous media …

Destructive impacts of COVID-19 pandemic worldwide necessitates taking more appropriate
measures for mitigating virus spread and development of the effective theranostic agents. In …

RNA interference (RNAi), an accurate and potent gene-silencing method, was first
experimentally documented in 1998 in Caenorhabditis elegans by Fire et al., who …

Small interfering RNA (siRNA) is a promising drug candidate, expected to have broad
therapeutic potentials toward various diseases including viral infections and cancer. With …

Conventional liver targeted system focuses on delivering drugs to liver, bringing toxicity on
hepatic normal tissues. The purpose of this study is to construct a new system capable of …

Gene editing technologies (GETs) could induce gene knockdown or gene knockout for
biomedical applications. The clinical success of gene silence by RNAi therapies pays …