[HTML][HTML] Antigenic evolution of SARS coronavirus 2

AZ Mykytyn, RAM Fouchier, BL Haagmans - Current Opinion in Virology, 2023 - Elsevier
SARS coronavirus 2 (SARS-CoV-2), the causative agent of COVID-19, emerged in China in
December 2019. Vaccines developed were very effective initially, however, the virus has …

Protein post-translational modification in SARS-CoV-2 and host interaction

N Cheng, M Liu, W Li, BY Sun, D Liu, G Wang… - Frontiers in …, 2023 - frontiersin.org
SARS-CoV-2 can cause lung diseases, such as pneumonia and acute respiratory distress
syndrome, and multi-system dysfunction. Post-translational modifications (PTMs) related to …

Interaction of SARS-CoV-2 with host cells and antibodies: experiment and simulation

H Nguyen, HL Nguyen, PD Lan, NQ Thai… - Chemical Society …, 2023 - pubs.rsc.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of
the devastating global COVID-19 pandemic announced by WHO in March 2020. Through …

Natural antibodies produced in vaccinated patients and COVID-19 convalescents recognize and hydrolyze oligopeptides corresponding to the S-protein of SARS-CoV …

AM Timofeeva, SE Sedykh, TA Sedykh, GA Nevinsky - Vaccines, 2023 - mdpi.com
The S-protein is the major antigen of the SARS-CoV-2 virus, against which protective
antibodies are generated. The S-protein gene was used in adenoviral vectors and mRNA …

In-depth characterization of protein N-glycosylation for a COVID-19 variant-design vaccine spike protein

J Huang, S Hou, J An, C Zhou - Analytical and bioanalytical chemistry, 2023 - Springer
COVID-19 is caused by SARS-CoV-2 infection and remains one of the biggest pandemics
around the world since 2019. Vaccination has proved to be an effective way of preventing …

Host Cell Proteases Involved in Human Respiratory Viral Infections and Their Inhibitors: A Review

B Lubinski, GR Whittaker - Viruses, 2024 - mdpi.com
Viral tropism is most commonly linked to receptor use, but host cell protease use can be a
notable factor in susceptibility to infection. Here we review the use of host cell proteases by …

Isoform-specific N-linked glycosylation of NaV channel α-subunits alters β-subunit binding sites

CA Beaudoin, M Kohli, SC Salvage, H Liu… - Journal of General …, 2025 - rupress.org
Voltage-gated sodium channel α-subunits (NaV1. 1–1.9) initiate and propagate action
potentials in neurons and myocytes. The NaV β-subunits (β1–4) have been shown to …

[HTML][HTML] Nanomolar anti-SARS-CoV-2 Omicron activity of the host-directed TMPRSS2 inhibitor N-0385 and synergistic action with direct-acting antivirals

J Pérez-Vargas, G Lemieux, CAH Thompson… - Antiviral Research, 2024 - Elsevier
SARS-CoV-2 Omicron subvariants with increased transmissibility and immune evasion are
spreading globally with alarming persistence. Whether the mutations and evolution of spike …

Difference in TMPRSS2 usage by Delta and Omicron variants of SARS-CoV-2: Implication for a sudden increase among children

S Kakee, K Kanai, A Tsuneki-Tokunaga, K Okuno… - Plos one, 2024 - journals.plos.org
It has been postulated from a combination of evidence that a sudden increase in COVID-19
cases among pediatric patients after onset of the Omicron wave was attributed to a reduced …

Structural proteins of human coronaviruses: what makes them different?

N Minigulov, K Boranbayev… - Frontiers in Cellular …, 2024 - frontiersin.org
Following COVID-19 outbreak with its unprecedented effect on the entire world, the interest
to the coronaviruses increased. The causative agent of the COVID-19, severe acute …