Polymeric delivery of therapeutic nucleic acids

R Kumar, CF Santa Chalarca, MR Bockman… - Chemical …, 2021 - ACS Publications
The advent of genome editing has transformed the therapeutic landscape for several
debilitating diseases, and the clinical outlook for gene therapeutics has never been more …

[HTML][HTML] Sol–gel based materials for biomedical applications

GJ Owens, RK Singh, F Foroutan, M Alqaysi… - Progress in materials …, 2016 - Elsevier
Sol–gel chemistry offers a flexible approach to obtaining a diverse range of materials. It
allows differing chemistries to be achieved as well as offering the ability to produce a wide …

Bioactive glass in tissue engineering

MN Rahaman, DE Day, BS Bal, Q Fu, SB Jung… - Acta biomaterialia, 2011 - Elsevier
This review focuses on recent advances in the development and use of bioactive glass for
tissue engineering applications. Despite its inherent brittleness, bioactive glass has several …

Self-assembly of DNA nanohydrogels with controllable size and stimuli-responsive property for targeted gene regulation therapy

J Li, C Zheng, S Cansiz, C Wu, J Xu, C Cui… - Journal of the …, 2015 - ACS Publications
Here, we report the synthesis and characterization of size-controllable and stimuli-
responsive DNA nanohydrogels as effective targeted gene delivery vectors. DNA …

Hydrogels as extracellular matrix mimics for 3D cell culture

MW Tibbitt, KS Anseth - Biotechnology and bioengineering, 2009 - Wiley Online Library
Methods for culturing mammalian cells ex vivo are increasingly needed to study cell and
tissue physiology and to grow replacement tissue for regenerative medicine. Two …

Hydrogels for tissue engineering

KY Lee, DJ Mooney - Chemical reviews, 2001 - ACS Publications
Every year, millions of patients suffer the loss or failure of an organ or tissue as a result of
accidents or disease. Over 8 million surgical procedures are performed to treat these …

Scaffold: a novel carrier for cell and drug delivery

T Garg, O Singh, S Arora… - Critical Reviews™ in …, 2012 - dl.begellhouse.com
Scaffolds are implants or injects, which are used to deliver cells, drugs, and genes into the
body. Different forms of polymeric scaffolds for cell/drug delivery are available:(1) a typical …

Bone tissue engineering: state of the art and future trends

AJ Salgado, OP Coutinho… - Macromolecular bioscience, 2004 - Wiley Online Library
Although several major progresses have been introduced in the field of bone regenerative
medicine during the years, current therapies, such as bone grafts, still have many limitations …

Cell culture: biology's new dimension

A Abbott - Nature, 2003 - go.gale.com
Let's hear it for the humble petri dish! Many of the seminal findings in cell and molecular
biology have come from cultures of cells grown cheaply and conveniently in these familiar …

Polymeric system for dual growth factor delivery

TP Richardson, MC Peters, AB Ennett… - Nature …, 2001 - nature.com
The development of tissues and organs is typically driven by the action of a number of
growth factors. However, efforts to regenerate tissues (eg, bone, blood vessels) typically rely …