Neurotrophic factor BDNF, physiological functions and therapeutic potential in depression, neurodegeneration and brain cancer

L Colucci-D'Amato, L Speranza, F Volpicelli - International journal of …, 2020 - mdpi.com
Brain-derived neurotrophic factor (BDNF) is one of the most distributed and extensively
studied neurotrophins in the mammalian brain. BDNF signals through the tropomycin …

Biochemical mechanisms underlying psychedelic-induced neuroplasticity

DE Olson - Biochemistry, 2022 - ACS Publications
In addition to producing profound subjective effects following acute administration,
psychedelic compounds can induce beneficial behavioral changes relevant to the treatment …

Pharmacological treatment of anxiety disorders: the role of the HPA axis

GE Tafet, CB Nemeroff - Frontiers in psychiatry, 2020 - frontiersin.org
Stress in general, and early life stress in particular, has been associated with the
development of anxiety and mood disorders. The molecular, biological and psychological …

[HTML][HTML] Age-dependent effects of tobacco smoke and nicotine on cognition and the brain: A systematic review of the human and animal literature comparing …

K Colyer-Patel, L Kuhns, A Weidema… - Neuroscience & …, 2023 - Elsevier
Cigarette smoking is often initiated during adolescence and an earlier age of onset is
associated with worse health outcomes later in life. Paradoxically, the transition towards …

Interplay between peripheral and central inflammation in obesity-promoted disorders: The impact on synaptic mitochondrial functions

M Crispino, G Trinchese, E Penna, F Cimmino… - International journal of …, 2020 - mdpi.com
The metabolic dysfunctions induced by high fat diet (HFD) consumption are not limited to
organs involved in energy metabolism but cause also a chronic low-grade systemic …

Psychedelic‐inspired approaches for treating neurodegenerative disorders

HN Saeger, DE Olson - Journal of neurochemistry, 2022 - Wiley Online Library
Psychedelics are increasingly being recognized for their potential to treat a wide range of
brain disorders including depression, post‐traumatic stress disorder (PTSD), and substance …

[HTML][HTML] Microbiota-gut-brain Axis Dysregulation in Alzheimer's disease: Multi-pathway effects and therapeutic potential

L Qu, Y Li, F Liu, Y Fang, J He, J Ma, T Xu… - Aging and …, 2024 - ncbi.nlm.nih.gov
An essential regulator of neurodegenerative conditions like Alzheimer's disease (AD) is the
gut microbiota. Alterations in intestinal permeability brought on by gut microbiota …

The serotonin-immune axis in preeclampsia

S Gumusoglu, S Scroggins, J Vignato… - Current hypertension …, 2021 - Springer
Abstract Purpose of Review To review the literature and detail the potential immune
mechanisms by which hyperserotonemia may drive pro-inflammation in preeclampsia and to …

Functional dimerization of serotonin receptors: role in health and depressive disorders

EV Mitroshina, EA Marasanova… - International journal of …, 2023 - mdpi.com
Understanding the neurobiological underpinnings of depressive disorder constitutes a
pressing challenge in the fields of psychiatry and neurobiology. Depression represents one …

Music affects functional brain connectivity and is effective in the treatment of neurological disorders

L Speranza, S Pulcrano, C Perrone-Capano… - Reviews in the …, 2022 - degruyter.com
In a million years, under the pressure of natural selection, hominins have acquired the
abilities for vocal learning, music, and language. Music is a relevant human activity, highly …