Vascular smooth muscle cells (VSMCs) are the major cell type in blood vessels. Unlike
many other mature cell types in the adult body, VSMC do not terminally differentiate but …

Ion channels play a central role in the regulation of nearly every cellular process. Dating
back to the classic 1952 Hodgkin–Huxley model of the generation of the action potential, ion …

The smooth muscle cell directly drives the contraction of the vascular wall and hence
regulates the size of the blood vessel lumen. We review here the current understanding of …

The impact of a Mediterranean diet on the intestinal microbiome has been linked to its health
benefits. We aim to evaluate the effects of a Mediterranean diet supplemented with dairy …

Abstract Calcium (Ca 2+) plays a central role in excitation, contraction, transcription, and
proliferation of vascular smooth muscle cells (VSMs). Precise regulation of intracellular Ca …

Diabetes affects millions of people worldwide. This devastating disease dramatically
increases the risk of developing cardiovascular disorders. A hallmark metabolic abnormality …

Ischemic stroke causes a heavy health burden worldwide, with over 10 million new cases
every year. Despite the high prevalence and mortality rate of ischemic stroke, the underlying …

Hydra is a cnidarian polyp with an anatomically simple neuromuscular system that can offer
evolutionary insights on the functional design of animal body plans. Using calcium imaging …

Ca2+ is a universal intracellular signal. The modulation of cytoplasmic Ca2+ concentration
regulates a plethora of cellular processes, such as: synaptic plasticity, neuronal survival …

Hypertension is one of the leading risk factors for stroke, myocardial infarction and untimely
death. The prevalence of hypertension is extremely high among the global population, and …