Solid phase peptide synthesis (SPPS) provides the possibility to chemically synthesize
peptides and proteins. Applying the method on hydrophilic structures is usually without …

α-Helical membrane proteins fulfill many vital roles in all living cells and constitute the
majority of drug targets. However, their relevance is in no way paralleled by our current …

An inherent dilemma in the study of the structural biology of membrane proteins is that it is
often necessary to use detergents to mimic the native lipid bilayer environment. This …

The coronavirus responsible for the severe acute respiratory syndrome contains a small
envelope protein, E, with putative involvement in host apoptosis and virus morphogenesis …

Membrane proteins play the central roles in a variety of cellular processes, ranging from
nutrient uptake and signalling, to cell-cell communication. Their biological functions are …

Detergents play a significant role in structural and functional characterisation of integral
membrane proteins (IMPs). IMPs reside in the biological membranes and exhibit a great …

Coronaviruses contain a small envelope membrane protein with cation-selective ion
channel activity mediated by its transmembrane domain (ETM). In a computational study, we …

Modification of a peptide-αthioester with a sequence of six arginines on the thioester leaving
group can render soluble all peptides derived from a polytopic integral membrane protein …

Small multidrug resistance (SMR) pumps represent a minimal paradigm of proton-coupled
membrane transport in bacteria, yet no high-resolution structure of an SMR protein is …

We have used pHLIP®[pH (low) insertion peptide] to study the roles of carboxyl groups in
transmembrane (TM) peptide insertion. pHLIP binds to the surface of a lipid bilayer as a …