Three of the most fundamental questions in biology are how individual cells differentiate to
form tissues, how tissues function in a coordinated and flexible fashion and which gene …

The progression through different steps of T-cell development, activation, and effector
function is tightly bound to specific cellular metabolic processes. Previous studies …

The recent advent of methods for high-throughput single-cell molecular profiling has
catalyzed a growing sense in the scientific community that the time is ripe to complete the …

Naive CD4+ T cells differentiate into functionally diverse T helper (Th) cell subsets. Th2 cells
play a pathogenic role in asthma, yet a clear picture of their transcriptional profile is lacking …

Motivation Single-cell RNA sequencing (scRNA-seq) technologies enable the study of
transcriptional heterogeneity at the resolution of individual cells and have an increasing …

The immune response is tailored to the environment in which it takes place. Immune cells
sense and adapt to changes in their surroundings, and it is now appreciated that in addition …

Alternative polyadenylation (APA), a phenomenon that RNA molecules with different 3′
ends originate from distinct polyadenylation sites of a single gene, is emerging as a …

Given the many cell types and molecular components of the human immune system, along
with vast variations across individuals, how should we go about developing causal and …

Highlights•Activation induces a programmed timed division burst before return to
quiescence.•Clonal integration of activation signals, stochastic probabilities and ongoing …

The liver parenchyma is composed of hepatocytes and bile duct epithelial cells (BECs).
Controversy exists regarding the cellular origin of human liver parenchymal tissue …