Proteomics has brought with it the hope of identifying novel biomarkers for diseases such as
cancer. This hope is built on the ability of proteomic technologies, such as mass …

Conspectus While immunoglobulins are well-known for their characteristic ability to bind
macromolecular antigens (ie, as antibodies during an immune response), the lipocalins …

Early diagnosis is important for effective disease management. Measurement of biomarkers
present at the local level of the skin could be advantageous in facilitating the diagnostic …

Lipocalin-type prostaglandin (PG) D2 synthase (L-PGDS) catalyzes the isomerization of
PGH2, a common precursor of the two series of PGs, to produce PGD2. PGD2 stimulates …

Juvenile systemic lupus erythematosus (JSLE) is characterised by onset before 18 years of
age and more severe disease phenotype, increased morbidity and mortality compared to …

L-PGDS [lipocalin-type PGD (prostaglandin D) synthase] is a dual-functional protein, acting
as a PGD2-producing enzyme and a lipid transporter. L-PGDS is a member of the lipocalin …

Iron plays many important roles in the brain, including involvement in myelination,
neurotransmission and electron transfer in the respiratory chain. Transferrin (Tf), an iron …

BACKGROUND: β-Trace protein (Btp) has been proposed as a valuable marker of
cerebrospinal fluid (CSF) leakage overcoming the drawbacks of β-2-transferrin (B-2Tr) …

Background Cerebrospinal fluid (CSF) is sequestered from blood by the blood-brain barrier
and directly communicates with brain parenchymal interstitial fluid, leading to contain …

Awareness of the importance of chronic adult hydrocephalus has been raised again with the
recent emergence of epidemiological studies. It is estimated that between 5 and 10% of …