Administration of noncompetitive NMDA/glutamate receptor antagonists, such as
phencyclidine (PCP) and ketamine, to humans induces a broad range of schizophrenic-like …

The contribution of glutamate to synaptic transmission, plasticity and development is well
established; current evidence is based on diverse approaches to decipher function and …

BACKGROUND: Currently, no pharmacological treatments for bipolar depression exist that
exert rapid (within hours) antidepressant or antisuicidal effects. We previously reported that …

Epidemiological studies have indicated an association between maternal bacterial and viral
infections during pregnancy and the higher incidence of schizophrenia in the resultant …

Existing treatments for major depressive disorder (MDD) usually take weeks to months to
achieve their antidepressant effects, and a significant number of patients do not have …

Rationale Latent inhibition (LI), namely, poorer performance on a learning task involving a
previously pre-exposed non-reinforced stimulus, is disrupted in the rat by the dopamine (DA) …

There is a great need for relevant animal models for investigating the effects of putative pro-
cognitive compounds. Compounds that impair learning and/or memory processes without …

Mood disorders such as bipolar disorder and major depressive disorder are common,
chronic, and recurrent conditions affecting millions of individuals worldwide. Existing …

Conditioned taste aversion (CTA) is a robust defence device protecting animals against
repeated consumption of toxic food. It is characterised by the ability of many animals to learn …

Conditioned taste aversion (CTA) is a well established learning and memory paradigm in
rats and mice that is considered to be a special form of classical conditioning. Rodents—as …