Mammalian cells encode three D cyclins (D1, D2, and D3) that coordinately function as
allosteric regulators of cyclin-dependent kinase 4 (CDK4) and CDK6 to regulate cell cycle …

Conformational diseases are caused by mutations altering the folding pathway or final
conformation of a protein. Many conformational diseases are caused by mutations in …

Multiple myeloma (MM) is an incurable plasma cell malignancy. The 26S proteasome
inhibitor, bortezomib, selectively induces apoptosis in MM cells; however, the nature of its …

Entry into, progression through, and exit from the G1 phase of the mammalian cell cycle in
response to extracellular mitogenic cues are presumed to be governed by cyclin-dependent …

Organelle interactions play a significant role in compartmentalizing metabolism and
signaling. Lipid droplets (LDs) interact with numerous organelles, including mitochondria …

The pregnancy complications of unexplained intrauterine growth restriction and early onset
preeclampsia are thought to share a common aetiology in placental malperfusion secondary …

CHOP is a non-ER localized transcription factor that is induced by a variety of adverse
physiological conditions including ER stress. Accumulation of unfolded proteins in the ER …

Disturbance in the folding capacity of the endoplasmic reticulum (ER), caused by a variety of
endogenous and exogenous insults, prompts a cellular stress condition known as ER stress …

In the broadest sense, cellular stress describes conditions wherein cells encounter and react
to a 'non-normal'state. Perturbations may originate through both extracellular and …

A large number of correlative studies have established that the activation of the unfolded
protein response (UPR) alters the cell's sensitivity to chemotherapeutic agents. Although the …