Photocatalytic late-stage C–H functionalization

P Bellotti, HM Huang, T Faber, F Glorius - Chemical Reviews, 2023 - ACS Publications
The emergence of modern photocatalysis, characterized by mildness and selectivity, has
significantly spurred innovative late-stage C–H functionalization approaches that make use …

Transition-metal-catalyzed C–S, C–Se, and C–Te bond formations via cross-coupling and atom-economic addition reactions. Achievements and challenges

IP Beletskaya, VP Ananikov - Chemical Reviews, 2022 - ACS Publications
In the present review, we discuss recent progress in the field of C–Z bond formation
reactions (Z= S, Se, Te) catalyzed by transition metals. Two complementary methodologies …

Photons or electrons? A critical comparison of electrochemistry and photoredox catalysis for organic synthesis

NES Tay, D Lehnherr, T Rovis - Chemical reviews, 2021 - ACS Publications
Redox processes are at the heart of synthetic methods that rely on either electrochemistry or
photoredox catalysis, but how do electrochemistry and photoredox catalysis compare? Both …

Late-stage functionalization for improving drug-like molecular properties

NJ Castellino, AP Montgomery, JJ Danon… - Chemical …, 2023 - ACS Publications
The development of late-stage functionalization (LSF) methodologies, particularly C–H
functionalization, has revolutionized the field of organic synthesis. Over the past decade …

Photoredox-catalyzed C–H functionalization reactions

N Holmberg-Douglas, DA Nicewicz - Chemical reviews, 2021 - ACS Publications
The fields of C–H functionalization and photoredox catalysis have garnered enormous
interest and utility in the past several decades. Many different scientific disciplines have …

A fruitful decade of organofluorine chemistry: new reagents and reactions

FL Qing, XY Liu, JA Ma, Q Shen, Q Song… - CCS …, 2022 - chinesechemsoc.org
The development of synthetic methods for the introduction of the fluorine atom and
fluoroalklyl groups into organic molecules has gained increased attention. Synthetic organic …

Multicomponent reactions and photo/electrochemistry join forces: atom economy meets energy efficiency

GA Coppola, S Pillitteri, EV Van der Eycken… - Chemical Society …, 2022 - pubs.rsc.org
Visible-light photoredox catalysis has been regarded as an extremely powerful tool in
organic chemistry, bringing the spotlight back to radical processes. The versatility of …

Radical philicity and its role in selective organic transformations

F Parsaee, MC Senarathna, PB Kannangara… - Nature Reviews …, 2021 - nature.com
Radical intermediates in organic chemistry lack a full octet of electrons and, thus, are
commonly said to be electron deficient. By denotation, such a statement is technically …

Visible light photocatalysis in the late-stage functionalization of pharmaceutically relevant compounds

R Cannalire, S Pelliccia, L Sancineto… - Chemical Society …, 2021 - pubs.rsc.org
The late stage functionalization (LSF) of complex biorelevant compounds is a powerful tool
to speed up the identification of structure–activity relationships (SARs) and to optimize …

Desulfonylation via radical process: recent developments in organic synthesis

XQ Chu, D Ge, YY Cui, ZL Shen, CJ Li - Chemical reviews, 2021 - ACS Publications
As the “chemical chameleon”, sulfonyl-containing compounds and their variants have been
merged with various types of reactions for the efficient construction of diverse molecular …