A large proportion of protein–protein interactions (PPIs) occur between a short peptide and a
globular protein domain; the peptides involved in surface interactions play important roles …

Peptides are a growing therapeutic class due to their unique spatial characteristics that can
target traditionally “undruggable” protein–protein interactions and surfaces. Despite their …

In the past decade, multicomponent reactions have experienced a renaissance as powerful
peptide macrocyclization tools enabling the rapid creation of skeletal complexity and …

As a versatile therapeutic modality, peptides attract much attention because of their great
binding affinity, low toxicity, and the capability of targeting traditionally “undruggable” protein …

Conspectus Multicomponent reactions (MCRs) encompass an exciting class of chemical
transformations that have proven success in almost all fields of synthetic organic chemistry …

There is a growing interest in constructing multicyclic peptide structures to expand the
chemical space of peptides. Conventional strategies for constructing large peptide structures …

Cancer is one of the diseases with the highest mortality rate. Treatments to mitigate cancer
are usually so intense and invasive that they weaken the patient to cure as dangerous as the …

For the first time, the Petasis (borono‐Mannich) reaction is employed for the multicomponent
labeling and stapling of peptides. The report includes the solid‐phase derivatization of …

Peptide stapling is traditionally used to lock peptide conformations into α-helical structures
using a variety of macrocyclization chemistries. In an endeavor to add a diversity-generating …

A new synthetic strategy for the development of multivalent antibacterial glycoconjugate
vaccines is described. The approach comprises the utilization of an isocyanide-based …