Until 15 years ago, vasculogenesis, the formation of new blood vessels from undifferentiated
cells, was thought to occur only during embryonic development. The discovery of circulating …

The tumor microenvironment (TME) is a highly intricate milieu, comprising a multitude of
components, including immune cells and stromal cells, that exert a profound influence on …

Tumor-associated vessels constitution is the result of angiogenesis, the hallmark of cancer
essential for tumor to develop in dimension and to spread throughout the organism. Tumor …

Endothelial cells (EC) are targets in gene therapy and regenerative medicine, but they are
inefficiently transduced with adeno-associated virus (AAV) vectors of various serotypes. To …

Purpose Breast cancer (BRCA) is the second most common malignancy in the world and the
most common in women. Here, we utilized publicly available BRCA dataset to investigate …

Immune checkpoints comprise diverse receptors and ligands including costimulatory and
inhibitory molecules, which play monumental roles in regulating the immune system …

Hypoxia-inducing pathologies as cancer develop pathologic and inefficient angiogenesis
which rules tumor facilitating microenvironment, a key target for therapy. As such, the …

The discovery of human induced pluripotent stem cells (hiPSCs) might pave the way toward
a long-sought solution for obtaining sufficient numbers of autologous cells for tissue …

Sarah Nanoparticles (SaNPs) are unique multicore iron oxide-based nanoparticles,
developed for the treatment of advanced cancer, following standard care, through the …

Cell therapy for vascular damage has been showing promises as alternative therapy for
endothelial dysfunctions since the discovery of the endothelial progenitor cells (EPCs) …