Nitric oxide (NO) is a small free radical with critical signaling roles in physiology and
pathophysiology. The generation of sufficient NO levels to regulate the resistance of the …

The acute respiratory distress syndrome (ARDS) is a common cause of respiratory failure in
critically ill patients and is defined by the acute onset of noncardiogenic pulmonary oedema …

▪ Abstract At the interface between the innate and adaptive immune systems lies the high-
output isoform of nitric oxide synthase (NOS2 or iNOS). This remarkable molecular machine …

Fractional exhaled nitric oxide (FeNO) has gained great clinical importance as a biomarker
of type 2 inflammation in chronic airway diseases such as asthma. FeNO originates primarily …

Background Pulmonary hypertension is characterized by abnormal thickening of the
pulmonary arteries and increased pulmonary vascular resistance. Nitric oxide is a potent …

Nitric oxide synthases (NOSs)'(L-arginine, NADPH: oxygen oxidoreductases (nitric oxide
forming); EC 1.14. 13.39) are unique among eukaryotic enzymes in being dimeric …

During the past decade a plethora of studies have unravelled the multiple roles of nitric
oxide (NO) in airway physiology and pathophysiology. In the respiratory tract, NO is …

Fire sweeps through the brush. In its aftermath, dormant seeds of chaparral, savanna, heath,
and scrub begin to germinate in response to a “go” signal in the smoke. Even though …

Asthma is a complex chronic inflammatory disease of the airways that involves the activation
of many inflammatory and structural cells, all of which release inflammatory mediators that …

Oxidation of lipoproteins is important for the initiation and propagation of the atherosclerotic
lesion and may involve secondary oxidants derived from nitric oxide. Nitric oxide (NO) reacts …