Aspects of the tumor microenvironment involved in immune resistance and drug resistance

K Khalaf, D Hana, JTT Chou, C Singh… - Frontiers in …, 2021 - frontiersin.org
The tumor microenvironment (TME) is a complex and ever-changing “rogue organ”
composed of its own blood supply, lymphatic and nervous systems, stroma, immune cells …

Challenges and controversies in human mesenchymal stem cell therapy

B Lukomska, L Stanaszek, E Zuba-Surma… - Stem cells …, 2019 - Wiley Online Library
Stem cell therapy is being intensely investigated within the last years. Expectations are high
regarding mesenchymal stem cell (MSC) treatment in translational medicine. However …

[HTML][HTML] Ethical and safety issues of stem cell-based therapy

V Volarevic, BS Markovic, M Gazdic… - … journal of medical …, 2018 - ncbi.nlm.nih.gov
Results obtained from completed and on-going clinical studies indicate huge therapeutic
potential of stem cell-based therapy in the treatment of degenerative, autoimmune and …

Skin tissue regeneration for burn injury

A Shpichka, D Butnaru, EA Bezrukov… - Stem cell research & …, 2019 - Springer
The skin is the largest organ of the body, which meets the environment most directly. Thus,
the skin is vulnerable to various damages, particularly burn injury. Skin wound healing is a …

Tissue engineering for clean meat production

T Ben-Arye, S Levenberg - Frontiers in Sustainable Food Systems, 2019 - frontiersin.org
Increasing public awareness of foodborne illnesses, factory farming, and the ecological
footprint of the meat industry, has generated the need for animal-free meat alternatives. In …

[HTML][HTML] Secretion of immunoregulatory cytokines by mesenchymal stem cells

D Kyurkchiev, I Bochev… - World journal of stem …, 2014 - ncbi.nlm.nih.gov
According to the minimal criteria of the International Society of Cellular Therapy,
mesenchymal stem cells (MSCs) are a population of undifferentiated cells defined by their …

Cancer stem cell secretome in the tumor microenvironment: a key point for an effective personalized cancer treatment

J López de Andrés, C Griñán-Lisón, G Jiménez… - Journal of hematology & …, 2020 - Springer
Cancer stem cells (CSCs) represent a tumor subpopulation responsible for tumor metastasis
and resistance to chemo-and radiotherapy, ultimately leading to tumor relapse. As a …

Same or not the same? Comparison of adipose tissue-derived versus bone marrow-derived mesenchymal stem and stromal cells

M Strioga, S Viswanathan, A Darinskas… - Stem cells and …, 2012 - liebertpub.com
Mesenchymal stem/stromal cells (MSCs) comprise a heterogeneous population of cells with
multilineage differentiation potential, the ability to modulate oxidative stress, and secrete …

Rebuilding the damaged heart: mesenchymal stem cells, cell-based therapy, and engineered heart tissue

S Golpanian, A Wolf, KE Hatzistergos… - Physiological …, 2016 - journals.physiology.org
Mesenchymal stem cells (MSCs) are broadly distributed cells that retain postnatal capacity
for self-renewal and multilineage differentiation. MSCs evade immune detection, secrete an …

Erythropoietin (EPO) as a key regulator of erythropoiesis, bone remodeling and endothelial transdifferentiation of multipotent mesenchymal stem cells (MSCs) …

AS Tsiftsoglou - Cells, 2021 - mdpi.com
Human erythropoietin (EPO) is an N-linked glycoprotein consisting of 166 aa that is
produced in the kidney during the adult life and acts both as a peptide hormone and …