International Union of Basic and Clinical Pharmacology. CX. Classification of receptors for 5-hydroxytryptamine; pharmacology and function
5-HT receptors expressed throughout the human body are targets for established
therapeutics and various drugs in development. Their diversity of structure and function …
therapeutics and various drugs in development. Their diversity of structure and function …
Serotonin and brain function: a tale of two receptors
RL Carhart-Harris, DJ Nutt - Journal of psychopharmacology, 2017 - journals.sagepub.com
Previous attempts to identify a unified theory of brain serotonin function have largely failed to
achieve consensus. In this present synthesis, we integrate previous perspectives with new …
achieve consensus. In this present synthesis, we integrate previous perspectives with new …
A review of central 5-HT receptors and their function
NM Barnes, T Sharp - Neuropharmacology, 1999 - Elsevier
It is now nearly 5 years since the last of the currently recognised 5-HT receptors was
identified in terms of its cDNA sequence. Over this period, much effort has been directed …
identified in terms of its cDNA sequence. Over this period, much effort has been directed …
Molecular, pharmacological and functional diversity of 5-HT receptors
Serotonin (5-hydroxytryptamine, 5-HT) is probably unique among the monoamines in that its
effects are subserved by as many as 13 distinct heptahelical, G-protein-coupled receptors …
effects are subserved by as many as 13 distinct heptahelical, G-protein-coupled receptors …
Distribution of the serotonin 5-HT2 receptor family mRNAs: comparison between 5-HT2A and 5-HT2C receptors
M Pompeiano, JM Palacios, G Mengod - Molecular brain research, 1994 - Elsevier
Because of their similarities, serotonin 5-HT 2, 5-HT 1C, and the recently described 5-HT 2F
receptors have been classified as members of the 5-HT 2 receptor family, and they have …
receptors have been classified as members of the 5-HT 2 receptor family, and they have …
5-Hydroxytryptamine2 and 5-hydroxytryptamine1A receptors mediate opposing responses on membrane excitability in rat association cortex
The effects of serotonin on pyramidal cells of layer V of the medial prefrontal cortex were
examined using intracellular recording techniques in rat brain slices in vitro. Bath …
examined using intracellular recording techniques in rat brain slices in vitro. Bath …
Autoregulation of serotonin neurons: role in antidepressant drug action
G Piñeyro, P Blier - Pharmacological reviews, 1999 - ASPET
The existence of an endogenous vasoconstrictor in blood serum (Stevens and Lee, 1984;
Brodie, 1900) and the presence in the gut of a substance that increases intestinal motility …
Brodie, 1900) and the presence in the gut of a substance that increases intestinal motility …
Understanding the effects of serotonin in the brain through its role in the gastrointestinal tract
The neuromodulatory arousal system imbues the nervous system with the flexibility and
robustness required to facilitate adaptive behaviour. While there are well understood …
robustness required to facilitate adaptive behaviour. While there are well understood …
The activities of drug inactive ingredients on biological targets
Excipients, considered “inactive ingredients,” are a major component of formulated drugs
and play key roles in their pharmacokinetics. Despite their pervasiveness, whether they are …
and play key roles in their pharmacokinetics. Despite their pervasiveness, whether they are …
AG Protein Couples Serotonin and GABAB Receptors to the Same Channels in Hippocampus
R Andrade, RC Malenka, RA Nicoll - Science, 1986 - science.org
Both serotonin and the selective γ-aminobutyric acidB (GABAB) agonist, baclofen, increase
potassium (K+) conductance in hippocampal pyramidal cells. Although these agonists act on …
potassium (K+) conductance in hippocampal pyramidal cells. Although these agonists act on …