The accumulation of protein inclusions is linked to many neurodegenerative diseases that
typically develop in older individuals, due to a combination of genetic and environmental …

Proteolytic cleavage represents a unique and irreversible posttranslational event regulating
the function and half-life of many intracellular and extracellular proteins. The …

Cholinergic transmission is critical to high-order brain functions such as memory, learning,
and attention. Alzheimer's disease (AD) is characterized by cognitive decline associated …

With the long-standing amyloid cascade hypothesis (ACH) largely discredited, there is an
acute need for a new all-encompassing interpretation of Alzheimer's disease (AD). Whereas …

ADAM (a disintegrin and metalloproteinase) is a family of widely expressed, transmembrane
and secreted proteins of approximately 750 amino acids in length with functions in cell …

Altered levels of sphingolipids and their metabolites in the brain, and the related
downstream effects on neuronal homeostasis and the immune system, provide a framework …

Redox-active metal ions, Cu (I/II) and Fe (II/III), are essential biological molecules for the
normal functioning of the brain, including oxidative metabolism, synaptic plasticity …

Alzheimer's disease (AD) represents a global burden in the economics of healthcare
systems. Amyloid-β (Aβ) peptides are formed by amyloid-β precursor protein (AβPP) …

Alzheimer's disease (AD) is the most common form of dementia and cases are rising
worldwide. The effort to fight this disease is hampered by a lack of disease-modifying …

Abstract Alzheimer's disease (AD), the most common neurodegenerative disease
worldwide, is caused by loss of neurons and synapses in central nervous system. Several …