Protein kinases represent a very pharmacologically attractive class of targets; however,
some members of the family still remain rather unexplored. The biology and therapeutic …

Alternative pre-mRNA splicing, which produces various mRNA isoforms with distinct
structures and functions from a single gene, is regulated by specific RNA-binding proteins …

Abstract N6-methyladenosine (m6A) regulates many aspects of RNA metabolism and is
involved in learning and memory processes. Yet, the impact of a dysregulation of post …

Neuronal alternative splicing is a key gene regulatory mechanism in the brain. However, the
spliceosome machinery is insufficient to fully specify splicing complexity. In considering the …

RNA splicing is highly prevalent in the brain and has strong links to neuropsychiatric
disorders; yet, the role of cell type–specific splicing and transcript-isoform diversity during …

Cell-specific alternative splicing modulates myriad cell functions and is disrupted in disease.
The mechanisms governing alternative splicing are known for relatively few genes and …

The brain processes information by transmitting signals through highly connected and
dynamic networks of neurons. Neurons use specific cellular structures, including axons …

Voltage-gated CaV2. 2 calcium channels are expressed in nociceptors at presynaptic
terminals, soma, and axons. CaV2. 2 channel inhibitors applied to the spinal cord relieve …

Alternative splicing of genes in the central nervous system is ubiquitous and utilizes many
different mechanisms. Splicing generates unique transcript or protein isoforms of the primary …

Opiate/opioid use disorder (OUD) is a chronic relapsing brain disorder that has increased in
prevalence in the last two decades in the United States. Understanding the molecular …