An increasing body of evidence highlights the strong potential for a diet rich in fruit and
vegetables to delay, and often prevent, the onset of chronic diseases, including …

The important life-supporting role of hydrogen sulfide (H2S) has evolved from bacteria to
plants, invertebrates, vertebrates, and finally to mammals. Over the centuries, however, H2S …

A potentially useful approach for drug discovery is to connect gene expression profiles of
disease-affected tissues (“disease signatures”) to drug signatures, but it remains to be …

An elaborate network of highly inducible proteins protects aerobic cells against the
cumulative damaging effects of reactive oxygen intermediates and toxic electrophiles, which …

Glucosinolates and isothiocyanates have both been objects of research for more than half a
century. Interest in these unique phytochemicals escalated following the discovery that …

Hormesis is a term used by toxicologists to refer to a biphasic dose–response to an
environmental agent characterized by a low dose stimulation or beneficial effect and a high …

Covering: 2000 to 2013 Oxidative stress is the central component of chronic diseases. The
nuclear factor erythroid 2-related factor 2/antioxidant response element (Nrf2/ARE) pathway …

Cruciferous vegetables hold a myriad of bioactive molecules that are renowned for
possessing unique medicinal benefits. Sulforaphane (SFN) is one of the potential …

Cellular protection against oxidative and electrophile toxicities is provided by two types of
small‐molecule antioxidants:(i) direct antioxidants, which are redox active, short‐lived, are …

Hypertension, myocardial infarction, atherosclerosis, arrhythmias and valvular heart
disease, coagulopathies and stroke, collectively known as cardiovascular diseases (CVDs) …