Ectodomain shedding (ES) is a post-translational protein modification process that plays key
roles in health and disease. Many neuronal and synaptic membrane proteins are known to …

A limitation of conventional bulk-tissue proteome studies in amyotrophic lateral sclerosis
(ALS) is the confounding of motor neuron (MN) signals by admixed non-MN proteins. Here …

Intrathecal synthesis of central nervous system (CNS)-reactive autoantibodies is observed
across patients with autoimmune encephalitis (AE), who show multiple residual …

Alzheimer's Disease (AD) and related dementias are a leading cause of death globally and
are predicted to increase in prevalence. Despite this expected increase in the prevalence of …

Polystyrene nano-plastics (PS-NPs) can be accumulated in the food chain and can
penetrate biological barriers to affect multiple physiological functions. However, the adverse …

As the most prevalent neurodevelopmental disorders in children, autism spectrum disorders
(ASD) are characterized by deficits in language development, social interaction, and …

Background Loss-of-function mutations in the contactin-associated protein-like 2
(CNTNAP2) gene are causal for neurodevelopmental disorders, including autism …

Mutations in the Contactin-associated protein-like 2 (CNTNAP2) gene are associated with
autism spectrum disorder (ASD), and ectodomain shedding of the CNTNAP2 protein plays a …

Unbiased proteomics has been employed to interrogate central nervous system (CNS)
tissues (brain, spinal cord) and fluid matrices (CSF, plasma) from amyotrophic lateral …

The contactin-associated protein-like 2 (CNTNAP2) gene is associated with multiple
neurodevelopmental disorders, including autism spectrum disorder (ASD), intellectual …