Since the discovery of AMP-activated protein kinase (AMPK) as a central regulator of energy
homeostasis, many exciting insights into its structure, regulation and physiological roles …

The AMP-activated protein kinase (AMPK) is a central regulator of multiple metabolic
pathways and may have therapeutic importance for treating obesity, insulin resistance, type …

Abstract Purpose of Review The global prevalence of type 2 diabetes (T2D) is escalating at
alarming rates, demanding the development of additional classes of therapeutics to further …

Background Insulin resistance not only occurs in obesity, but also in lipodystrophy. Although
adipose tissue mass affects metabolic fluxes and participates in interorgan crosstalk, the role …

Complex multicellular organisms require a coordinated response from multiple tissues to
maintain whole-body homeostasis in the face of energetic stressors such as fasting, cold …

Vascular mimicry is induced by a wide array of genes with functions related to cancer
stemness, hypoxia, angiogenesis and autophagy. Vascular mimicry competent (VM …

Activation of hepatic stellate cells (HSCs) is a pivotal event in liver fibrosis, characterized by
dramatic disappearance of lipid droplets (LDs). Although LD disappearance has long been …

Long-chain acyl-CoAs (LC-acyl-CoAs) are important intermediary metabolites and are also
thought to function as intracellular signaling molecules; however, the direct effects of LC-acyl …

Impaired angiogenesis is a hallmark of metabolically dysfunctional adipose tissue in obesity.
However, the underlying mechanisms restricting angiogenesis within this context remain ill …

Methods: Male obesity-resistant A/J and obesity-prone C57BL/6J mice maintained at 30 C
were exposed to 6 C for 2 or 7 days. In epididymal WAT (eWAT), TAG synthesis and DNL …