Blood–brain-barriers in aging and in Alzheimer's disease
The aging process correlates with a progressive failure in the normal cellular and organ
functioning; these alterations are aggravated in Alzheimer's disease (AD). In both aging and …
functioning; these alterations are aggravated in Alzheimer's disease (AD). In both aging and …
[HTML][HTML] Lipocalin 2 as a link between ageing, risk factor conditions and age-related brain diseases
DW Dekens, ULM Eisel, L Gouweleeuw… - Ageing research …, 2021 - Elsevier
Chronic (neuro) inflammation plays an important role in many age-related central nervous
system (CNS) diseases, including Alzheimer's disease, Parkinson's disease and vascular …
system (CNS) diseases, including Alzheimer's disease, Parkinson's disease and vascular …
Regulatory effects of quercetin on M1/M2 macrophage polarization and oxidative/antioxidative balance
Macrophage polarization plays essential and diverse roles in most diseases, such as
atherosclerosis, adipose tissue inflammation, and insulin resistance. Homeostasis …
atherosclerosis, adipose tissue inflammation, and insulin resistance. Homeostasis …
A TRPV4-dependent neuroimmune axis in the spinal cord promotes neuropathic pain
Microglia, resident macrophages of the CNS, are essential to brain development,
homeostasis, and disease. Microglial activation and proliferation are hallmarks of many CNS …
homeostasis, and disease. Microglial activation and proliferation are hallmarks of many CNS …
Lipocalin-2 protects the brain during inflammatory conditions
Sepsis is a prevalent health issue that can lead to central nervous system (CNS)
inflammation with long-term behavioral and cognitive alterations. Using unbiased proteomic …
inflammation with long-term behavioral and cognitive alterations. Using unbiased proteomic …
Astrocyte‐derived lipocalin‐2 mediates hippocampal damage and cognitive deficits in experimental models of vascular dementia
Abstract Lipocalin‐2 (LCN2) has diverse functions in multiple pathophysiological conditions;
however, its pathogenic role in vascular dementia (VaD) is unknown. Here, we investigated …
however, its pathogenic role in vascular dementia (VaD) is unknown. Here, we investigated …
From the periphery to the brain: Lipocalin-2, a friend or foe?
AC Ferreira, S Dá Mesquita, JC Sousa… - Progress in …, 2015 - Elsevier
Abstract Lipocalin-2 (LCN2) is an acute-phase protein that, by binding to iron-loaded
siderophores, acts as a potent bacteriostatic agent in the iron-depletion strategy of the …
siderophores, acts as a potent bacteriostatic agent in the iron-depletion strategy of the …
Diverse functional roles of lipocalin-2 in the central nervous system
Abstract Lipocalin-2 (LCN2) is an acute phase protein with multiple functions that has
garnered a great deal of interest over the last decade. However, its precise role in the …
garnered a great deal of interest over the last decade. However, its precise role in the …
[HTML][HTML] Role of lipocalin 2 in stroke
RY Zhao, PJ Wei, X Sun, DH Zhang, QY He, J Liu… - Neurobiology of …, 2023 - Elsevier
Stroke is the second leading cause of death worldwide; however, the treatment choices
available to neurologists are limited in clinical practice. Lipocalin 2 (LCN2) is a secreted …
available to neurologists are limited in clinical practice. Lipocalin 2 (LCN2) is a secreted …
Mechanisms underlying HIV-associated cognitive impairment and emerging therapies for its management
People living with HIV are affected by the chronic consequences of neurocognitive
impairment (NCI) despite antiretroviral therapies that suppress viral replication, improve …
impairment (NCI) despite antiretroviral therapies that suppress viral replication, improve …