Microparticles, microcapsules and microspheres: A review of recent developments and prospects for oral delivery of insulin

CY Wong, H Al-Salami, CR Dass - International journal of pharmaceutics, 2018 - Elsevier
Diabetes mellitus is a chronic metabolic health disease affecting the homeostasis of blood
sugar levels. However, subcutaneous injection of insulin can lead to patient non …

Sugar-lowering drugs for type 2 diabetes mellitus and metabolic syndrome—Review of classical and new compounds: Part-I

R Vieira, SB Souto, E Sánchez-López… - Pharmaceuticals, 2019 - mdpi.com
Diabetes mellitus (DM) is a metabolic disorder characterized by chronic hyperglycemia
together with disturbances in the metabolism of carbohydrates, proteins and fat, which in …

Nanoparticle delivery systems in the treatment of diabetes complications

EB Souto, SB Souto, JR Campos, P Severino… - Molecules, 2019 - mdpi.com
Diabetes mellitus, an incurable metabolic disease, is characterized by changes in the
homeostasis of blood sugar levels, being the subcutaneous injection of insulin the first line …

In vivo pharmacokinetics and biodistribution of resveratrol-loaded solid lipid nanoparticles for brain delivery

S Jose, SS Anju, TA Cinu, NA Aleykutty… - International journal of …, 2014 - Elsevier
Resveratrol is a potent anticancer. However, because of its low half-life (< 0.25 h) the
molecule is difficult to achieve the therapeutic concentration at the site of action. The aim of …

New nanotechnologies for the treatment and repair of skin burns infections

EB Souto, AF Ribeiro, MI Ferreira, MC Teixeira… - International journal of …, 2020 - mdpi.com
Burn wounds are highly debilitating injuries, with significant morbidity and mortality rates
worldwide. In association with the damage of the skin integrity, the risk of infection is …

Loading, release profile and accelerated stability assessment of monoterpenes-loaded solid lipid nanoparticles (SLN)

A Zielińska, NR Ferreira, A Feliczak-Guzik… - Pharmaceutical …, 2020 - Taylor & Francis
Glycerol monostearate solid lipid nanoparticles (SLN) were produced by hot high-pressure
homogenization technique to load alpha-pinene, citral, geraniol or limonene. SLN were …

Sucupira oil-loaded nanostructured lipid carriers (NLC): Lipid screening, factorial design, release profile, and cytotoxicity

R Vieira, P Severino, LA Nalone, SB Souto, AM Silva… - Molecules, 2020 - mdpi.com
Essential oils are odorant liquid oily products consisting of a complex mixture of volatile
compounds obtained from a plant raw material. They have been increasingly proven to act …

(+)-Limonene 1, 2-epoxide-loaded slns: Evaluation of drug release, antioxidant activity, and cytotoxicity in an HaCaT cell line

EB Souto, A Zielinska, SB Souto, A Durazzo… - International Journal of …, 2020 - mdpi.com
In this work, we developed a solid lipid nanoparticle (SLN) formulation with (+)-limonene 1, 2-
epoxide and glycerol monostearate (Lim-SLNs), stabilized with Poloxamer® 188 in aqueous …

New glucose oxidase-immobilized stimuli-responsive dextran nanoparticles for insulin delivery

S Jamwal, B Ram, S Ranote, R Dharela… - International journal of …, 2019 - Elsevier
Designing strategies for the use of biopolymer-based nanoparticles as drug delivery carriers
is a considerable challenge in pharmaceutical science. Present study reports synthesis of a …

Stabilization challenges and formulation strategies associated with oral biologic drug delivery systems

V Truong-Le, PM Lovalenti, AM Abdul-Fattah - Advanced drug delivery …, 2015 - Elsevier
Delivery of proteins to mucosal tissues of GI tract typically utilize formulations which protect
against proteolysis and target the mucosal tissues. Using case studies from literature and …