Non-pial neocortical astrocytes have historically been thought to comprise largely a
nondiverse population of protoplasmic astrocytes. Here we show that astrocytes of the …

Astrocytes are a major type of glial cells that have essential functions in development and
homeostasis of the central nervous system (CNS). Immature astrocytes in the developing …

Chromatin plays a key role in regulating gene expression programs necessary for the
orderly progress of development and for preventing changes in cell identity that can lead to …

A broad molecular framework of how neural stem cells are specified toward astrocyte fate
during brain development has proven elusive. Here we perform comprehensive and …

Reactive astrocytes in Amyotrophic Lateral Sclerosis (ALS) change their molecular
expression pattern and release toxic factors that contribute to neurodegeneration and …

Neocortex expansion is largely based on the proliferative capacity of basal progenitors
(BPs), which is increased by extracellular matrix (ECM) components via integrin signaling …

Early-life metabolic stress has been demonstrated to affect brain development, persistently
influence brain plasticity and to exert multigenerational effects on cognitive functions …

White matter injuries (WMIs) are the leading cause of neurologic impairment in infants born
premature. There are no treatment options available. The most common forms of WMIs in …

Increasing evidence indicates that cellular identity can be reduced to the distinct gene
regulatory networks controlled by transcription factors (TFs). However, redundancy exists in …

Background: Although quiescent neural stem cells (NSCs) in the adult hippocampus
proliferate in response to neurogenic stimuli and subsequently give rise to new neurons …