Bidirectional learning in upbound and downbound microzones of the cerebellum

CI De Zeeuw - Nature Reviews Neuroscience, 2021 - nature.com
Over the past several decades, theories about cerebellar learning have evolved. A relatively
simple view that highlighted the contribution of one major form of heterosynaptic plasticity to …

Spatiotemporal firing patterns in the cerebellum

CI De Zeeuw, FE Hoebeek, LWJ Bosman… - Nature Reviews …, 2011 - nature.com
Neurons are generally considered to communicate information by increasing or decreasing
their firing rate. However, in principle, they could in addition convey messages by using …

Cerebellar long-term depression: characterization, signal transduction, and functional roles

M Ito - Physiological reviews, 2001 - journals.physiology.org
Cerebellar Purkinje cells exhibit a unique type of synaptic plasticity, namely, long-term
depression (LTD). When two inputs to a Purkinje cell, one from a climbing fiber and the other …

Motor learning and the cerebellum

CI De Zeeuw, MM Ten Brinke - Cold Spring Harbor …, 2015 - cshperspectives.cshlp.org
Although our ability to store semantic declarative information can nowadays be readily
surpassed by that of simple personal computers, our ability to learn and express procedural …

Timing and plasticity in the cerebellum: focus on the granular layer

E D'Angelo, CI De Zeeuw - Trends in neurosciences, 2009 - cell.com
Two of the most striking properties of the cerebellum are its control in timing of motor
operations and its ability to adapt behavior to new sensorimotor associations. Here, we …

[PDF][PDF] Expression of a protein kinase C inhibitor in Purkinje cells blocks cerebellar LTD and adaptation of the vestibulo-ocular reflex

CI De Zeeuw, C Hansel, F Bian, SKE Koekkoek… - Neuron, 1998 - cell.com
Cerebellar long-term depression (LTD) is a model system for neuronal information storage
that has an absolute requirement for activation of protein kinase C (PKC). It has been …

On climbing fiber signals and their consequence (s)

JI Simpson, DR Wylie, CI De Zeeuw - Behavioral and Brain Sciences, 1996 - cambridge.org
The persistence of many contrasting notions of climbing fiber function after years of
investigation testifies that the issue of climbing fiber contributions to cerebellar transactions …

A comparison of video and magnetic search coil recordings of mouse eye movements

JS Stahl, AM Van Alphen, CI De Zeeuw - Journal of neuroscience methods, 2000 - Elsevier
Interest in connecting molecular biology and behavior is motivating research into the eye
movements of mice. Unfortunately, recording eye movements in this diminutive animal is …

The roles of the olivocerebellar pathway in motor learning and motor control. A consensus paper

EJ Lang, R Apps, F Bengtsson, NL Cerminara… - The Cerebellum, 2017 - Springer
For many decades, the predominant view in the cerebellar field has been that the
olivocerebellar system's primary function is to induce plasticity in the cerebellar cortex …

[HTML][HTML] SK2 channels in cerebellar Purkinje cells contribute to excitability modulation in motor-learning–specific memory traces

G Grasselli, HJ Boele, HK Titley, N Bradford… - PLoS …, 2020 - journals.plos.org
Neurons store information by changing synaptic input weights. In addition, they can adjust
their membrane excitability to alter spike output. Here, we demonstrate a role of such …