Natural products: An upcoming therapeutic approach to cancer

S Dutta, S Mahalanobish, S Saha, S Ghosh… - Food and Chemical …, 2019 - Elsevier
Cancer is one of the leading causes of death across the world. Different environmental and
anthropogenic factors initiate mutations in different functional genes of growth factors and …

Insulin-like growth factor 1 (IGF-1) signaling in glucose metabolism in colorectal cancer

A Kasprzak - International journal of molecular sciences, 2021 - mdpi.com
Colorectal cancer (CRC) is one of the most common aggressive carcinoma types worldwide,
characterized by unfavorable curative effect and poor prognosis. Epidemiological data re …

Targeting pyruvate dehydrogenase kinase signaling in the development of effective cancer therapy

S Anwar, A Shamsi, T Mohammad, A Islam… - … et Biophysica Acta (BBA …, 2021 - Elsevier
Pyruvate is irreversibly decarboxylated to acetyl coenzyme A by mitochondrial pyruvate
dehydrogenase complex (PDC). Decarboxylation of pyruvate is considered a crucial step in …

Resveratrol: An overview of its anti-cancer mechanisms

M Elshaer, Y Chen, XJ Wang, X Tang - Life sciences, 2018 - Elsevier
Cancer is one of the leading causes of death worldwide. Chemotherapy and radiotherapy
are the conventional primary treatments for cancer patients. However, most of cancer cells …

Insight into polyphenol and gut microbiota crosstalk: are their metabolites the key to understand protective effects against metabolic disorders?

M Koudoufio, Y Desjardins, F Feldman, S Spahis… - Antioxidants, 2020 - mdpi.com
Lifestyle factors, especially diet and nutrition, are currently regarded as essential avenues to
decrease modern-day cardiometabolic disorders (CMD), including obesity, metabolic …

Combination therapy using polyphenols: An efficient way to improve antitumoral activity and reduce resistance

AF Vladu, D Ficai, AG Ene, A Ficai - International Journal of Molecular …, 2022 - mdpi.com
Polyphenols represent a structural class of mainly natural organic chemicals that contain
multiple phenol structural units. The beneficial properties of polyphenols have been …

Potential therapeutic targets of resveratrol, a plant polyphenol, and its role in the therapy of various types of cancer

SA Almatroodi, M A. Alsahli, A SM Aljohani… - Molecules, 2022 - mdpi.com
Cancer is among the most prominent causes of mortality worldwide. Different cancer therapy
modes employed, including chemotherapy and radiotherapy, have been reported to be …

Colorectal cancer (CRC) as a multifactorial disease and its causal correlations with multiple signaling pathways

M Wan, Y Wang, Z Zeng, B Deng, B Zhu… - Bioscience …, 2020 - portlandpress.com
Colorectal cancer (CRC) is the third most common malignancy and one of the leading
causes of cancer-related death among men worldwide. CRC is a multifactor digestive …

Targeting lactate metabolism and glycolytic pathways in the tumor microenvironment by natural products: A promising strategy in combating cancer

L Kooshki, P Mahdavi, S Fakhri, EK Akkol, H Khan - Biofactors, 2022 - Wiley Online Library
Anticancer drugs are not purely effective because of their toxicity, side effects, high cost,
inaccessibility, and associated resistance. On the other hand, cancer is a complex public …

Modulation of dysregulated cancer metabolism by plant secondary metabolites: A mechanistic review

S Fakhri, SZ Moradi, MH Farzaei, A Bishayee - Seminars in cancer biology, 2022 - Elsevier
Several signaling pathways and basic metabolites are responsible for the control of
metabolism in both normal and cancer cells. As emerging hallmarks of cancer metabolism …