[HTML][HTML] Drug development for refractory epilepsy: the past 25 years and beyond
Despite the exponential growth of approved antiepileptic drugs (AEDs) over the past 25
years, epilepsy remains uncontrolled in approximately a third of patients. This article …
years, epilepsy remains uncontrolled in approximately a third of patients. This article …
Vigabatrin: a review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in epilepsy and disorders of motor control
SM Grant, RC Heel - Drugs, 1991 - Springer
Synopsis Vigabatrin was specifically designed to enhance γ-aminobutyric acid (GABA)
function in the CNS. By increasing brain concentrations of this inhibitory neurotransmitter the …
function in the CNS. By increasing brain concentrations of this inhibitory neurotransmitter the …
Vigabatrin: 2008 update
L James Willmore, MB Abelson, E Ben‐Menachem… - …, 2009 - Wiley Online Library
Vigabatrin (VGB) is a structural analogue of γ‐aminobutyric acid (GABA) that irreversibly
inhibits GABA‐transaminase (GABA‐T), increasing brain levels of GABA. VGB is under …
inhibits GABA‐transaminase (GABA‐T), increasing brain levels of GABA. VGB is under …
Drug treatment of epilepsy in the century of the ILAE: the second 50 years, 1959–2009
SD Shorvon - Epilepsia, 2009 - Wiley Online Library
The drug therapy of epilepsy evolved enormously in this 50 year period. Advances in
therapeutics included the incorporation of pharmacokinetics into clinical practice, enormous …
therapeutics included the incorporation of pharmacokinetics into clinical practice, enormous …
Safety and efficacy of vigabatrin and carbamazepine in ne wly diagnosed epilepsy: a multicentre randomised double-blind study
D Chadwick - The Lancet, 1999 - thelancet.com
Background Vigabatrin is a newly licensed drug for use in patients with epilepsy. We
investigated whether this drug was comparable to standard first-line monotherapy in efficacy …
investigated whether this drug was comparable to standard first-line monotherapy in efficacy …
[HTML][HTML] Antiepileptic drug treatment in children with epilepsy
Most children with new-onset epilepsy achieve seizure freedom with appropriate
antiepileptic drugs (AEDs). However, nearly 20% will continue to have seizures despite …
antiepileptic drugs (AEDs). However, nearly 20% will continue to have seizures despite …
Mechanism of action of vigabatrin: correcting misperceptions
E Ben‐Menachem - Acta neurologica scandinavica, 2011 - Wiley Online Library
Ben‐Menachem E. Mechanism of action of vigabatrin: correcting misperceptions. Acta
Neurol Scand: 2011: 124 (Suppl. 192): 5–15.© 2011 John Wiley & Sons A/S. Discovered …
Neurol Scand: 2011: 124 (Suppl. 192): 5–15.© 2011 John Wiley & Sons A/S. Discovered …
Clinical effectiveness, tolerability and cost-effectiveness of newer drugs for epilepsy in adults: a systematic review and economic evaluation
J Wilby, A Kainth, N Hawkins… - Health Technology …, 2005 - eprints.whiterose.ac.uk
The aim of this review was to examine the clinical effectiveness, tolerability and cost-
effectiveness of newer drugs for epilepsy in adults. For the purposes of this review newer …
effectiveness of newer drugs for epilepsy in adults. For the purposes of this review newer …
Design and mechanism of GABA aminotransferase inactivators. Treatments for epilepsies and addictions
RB Silverman - Chemical reviews, 2018 - ACS Publications
When the brain concentration of the inhibitory neurotransmitter γ-aminobutyric acid (GABA)
diminishes below a threshold level, the excess neuronal excitation can lead to convulsions …
diminishes below a threshold level, the excess neuronal excitation can lead to convulsions …
New antiepileptic drugs: review on drug interactions
H Hachad, I Ragueneau-Majlessi… - Therapeutic drug …, 2002 - journals.lww.com
During the Past decade, nine new antiepileptic drugs (AEDs) namely, Felbamate,
Gabapentin, Levetiracetam, Lamotrigine, Oxcarbazepine, Tiagabine, Topiramate, Vigabatrin …
Gabapentin, Levetiracetam, Lamotrigine, Oxcarbazepine, Tiagabine, Topiramate, Vigabatrin …