Lipid droplets are cytosolic fat storage organelles present in most eukaryotic cells. Long
regarded merely as inert fat reservoirs, they are now emerging as major regulators of …

Cancer cells possess remarkable abilities to adapt to adverse environmental conditions.
Their survival during severe nutrient and oxidative stress depends on their capacity to …

Fatty acids are the most efficient substrates for energy production in vertebrates and are
essential components of the lipids that form biological membranes. Synthesis of …

Lipolysis is the process by which triglycerides (TGs) are hydrolyzed to free fatty acids (FFAs)
and glycerol. In adipocytes, this is achieved by sequential action of adipose TG lipase …

Lipolysis is the biochemical pathway responsible for the catabolism of triacylglycerol (TAG)
stored in cellular lipid droplets. The hydrolytic cleavage of TAG generates non-esterified fatty …

Elevated circulating fatty acids (FAs) contribute to the development of obesity-associated
metabolic complications such as insulin resistance (IR) and non-alcoholic fatty liver disease …

Triacylglycerol (TAG) is the primary unit of energy storage in eukaryotic cells. TAG comprises
more than 90% of the content of white adipocytes, and TAG synthesis is essential in …

Adipose triglyceride lipase (ATGL) has been discovered 14 years ago and revised our view
on intracellular triglyceride (TG) mobilization–a process termed lipolysis. ATGL initiates the …

Lipolysis is defined as the sequential hydrolysis of triacylglycerol (TAG) stored in cell lipid
droplets. For many years, it was believed that hormone-sensitive lipase (HSL) and …

Monoglyceride lipase (MGL) influences energy metabolism by at least two mechanisms.
First, it hydrolyzes monoacylglycerols (MG) into fatty acids and glycerol. These products can …