The possible link between hIAPP accumulation and β-cell death in diabetic patients has
inspired numerous studies focusing on amyloid structures and aggregation pathways of this …

Paramagnetic metal ions offer outstanding opportunities for protein studies by nuclear
magnetic resonance (NMR) spectroscopy. The paramagnetic effects manifested in the NMR …

Insulin-degrading enzyme (IDE) is a ubiquitous zinc peptidase of the inverzincin family,
which has been initially discovered as the enzyme responsible for insulin catabolism; …

Characterizing mechanisms of protein homeostasis, a process of balancing between protein
synthesis and protein degradation, is important for understanding the potential causes of …

Copper (Cu), a crucial trace element in physiological processes, has garnered significant
interest for its involvement in cancer progression and potential therapeutic applications. The …

Proliferation and programmed cell death are tightly correlated with the ubiquitin–proteasome
system (UPS). Alterations in the UPS may be implicated in pathological conditions such as …

Nasopharyngeal carcinoma (NPC) represents a molecularly paradigmatic tumor given the
complex diversity of environmental as well as host dependent factors that are closely …

Background: There is mounting urgency to find new drugs for the treatment of
neurodegenerative disorders. A large number of reviews have exhaustively described either …

The aim of this study is to verify if water-soluble porphyrins can be used as proteasome
inhibitors. We have found that cationic porphyrins inhibit proteasome peptidase activities …

Substantial evidence has accumulated over the last decade indicating that diverse age-
related neurodegenerative disorders share a common pathogenic mechanism: the …