The emergence of bacterial resistance has motivated researchers to discover new
antibacterial agents. Nowadays, fluoroquinolones keep their status as one of the essential …

Abstract The ESKAPE (Escherichia coli/E. coli, Staphylococcus aureus/S. aureus, Klebsiella
pneumonia/K. pneumoniae, Acinetobacter Baumannii/A. baumannii, Pseudomonas …

ESKAPE pathogens, as priority 1 and 2 pathogens, are prevalent infectious agents
associated with high morbidity and mortality. ESKAPE can cause broad-spectrum diseases …

The emergence of serious bacterial resistance towards clinical oxacins poses a
considerable threat to global public health, necessitating the development of novel structural …

One of the leading causes of death worldwide among women is breast cancer. Thus,
discovering new multi-target anti-breast cancer drugs is mandatory to stimulate nitric oxide …

Abstract Six novel ciprofloxacin-1, 2, 3-triazole hybrids (6a-f) were synthesized via click
reaction, by reacting of methyl 1-cyclopropyl-6-fluoro-4-oxo-7-(4-(3-oxobutanoyl) piperazin-1 …

Nowadays, infectious diseases caused by microorganisms are a major threat to human
health, mostly because of drug resistance, multi-drug resistance and extensive-drug …

Fluoroquinolones have been studied for more than half a century. Since the 1960s, four
generations of these synthetic antibiotics have been created and successfully introduced …

A series of new unique acetylene derivatives of 8-hydroxy-and 8-methoxyquinoline-5-
sulfonamide 3a–f and 6a–f were prepared by reactions of 8-hydroxy-and 8 …

This work identified a class of cyanomethylquinolones (CQs) and their carboxyl analogues
as potential multitargeting antibacterial candidates. Most of the prepared compounds …