Glucose metabolic crosstalk and regulation in brain function and diseases
Brain glucose metabolism, including glycolysis, the pentose phosphate pathway, and
glycogen turnover, produces ATP for energetic support and provides the precursors for the …
glycogen turnover, produces ATP for energetic support and provides the precursors for the …
Mitochondrial mechanisms of neuronal cell death: potential therapeutics
Mitochondria lie at the crossroads of neuronal survival and cell death. They play important
roles in cellular bioenergetics, control intracellular Ca2+ homeostasis, and participate in key …
roles in cellular bioenergetics, control intracellular Ca2+ homeostasis, and participate in key …
[HTML][HTML] Recent advances in the development of nanomedicines for the treatment of ischemic stroke
Ischemic stroke is still a serious threat to human life and health, but there are few therapeutic
options available to treat stroke because of limited blood-brain penetration. The …
options available to treat stroke because of limited blood-brain penetration. The …
Oxidative stress in diabetic peripheral neuropathy: Pathway and mechanism-based treatment
Q Lin, K Li, Y Chen, J Xie, C Wu, C Cui, B Deng - Molecular Neurobiology, 2023 - Springer
Diabetic peripheral neuropathy (DPN) is a major complication of diabetes mellitus with a
high incidence. Oxidative stress, which is a crucial pathophysiological pathway of DPN, has …
high incidence. Oxidative stress, which is a crucial pathophysiological pathway of DPN, has …
Role of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) in DNA repair
Abstract Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is widely known as a
glycolytic enzyme. Nevertheless, various functions of GAPDH have been found that are …
glycolytic enzyme. Nevertheless, various functions of GAPDH have been found that are …
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) aggregation causes mitochondrial dysfunction during oxidative stress-induced cell death
H Nakajima, M Itakura, T Kubo, A Kaneshige… - Journal of Biological …, 2017 - ASBMB
Glycolytic glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a multifunctional protein
that also mediates cell death under oxidative stress. We reported previously that the active …
that also mediates cell death under oxidative stress. We reported previously that the active …
The role of endothelial dysfunction and oxidative stress in cerebrovascular diseases
P Scicchitano, F Cortese, M Gesualdo… - Free radical …, 2019 - Taylor & Francis
Cerebrovascular diseases (CBD) are one of the most dangerous complications of
atherosclerosis. The clinical consequences of CBD deeply impact quality of life and the …
atherosclerosis. The clinical consequences of CBD deeply impact quality of life and the …
Poly (ADP-ribose) polymerase-1 hyperactivation in neurodegenerative diseases: The death knell tolls for neurons
P Narne, V Pandey, PK Simhadri… - Seminars in cell & …, 2017 - Elsevier
Neurodegeneration is a salient feature of chronic refractory brain disorders like Alzheimer's,
Parkinson's, Huntington's, amyotropic lateral sclerosis and acute conditions like cerebral …
Parkinson's, Huntington's, amyotropic lateral sclerosis and acute conditions like cerebral …
UCP2 inhibition induces ROS/Akt/mTOR axis: Role of GAPDH nuclear translocation in genipin/everolimus anticancer synergism
I Dando, R Pacchiana, E Dalla Pozza, I Cataldo… - Free Radical Biology …, 2017 - Elsevier
Several studies indicate that mitochondrial uncoupling protein 2 (UCP2) plays a pivotal role
in cancer development by decreasing reactive oxygen species (ROS) produced by …
in cancer development by decreasing reactive oxygen species (ROS) produced by …
[HTML][HTML] Mutant p53 prevents GAPDH nuclear translocation in pancreatic cancer cells favoring glycolysis and 2-deoxyglucose sensitivity
G Butera, R Pacchiana, N Mullappilly… - … et Biophysica Acta (BBA …, 2018 - Elsevier
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive and devastating
human malignancies. In about 70% of PDACs the tumor suppressor gene TP53 is mutated …
human malignancies. In about 70% of PDACs the tumor suppressor gene TP53 is mutated …