Brain glucose metabolism, including glycolysis, the pentose phosphate pathway, and
glycogen turnover, produces ATP for energetic support and provides the precursors for the …

Mitochondria lie at the crossroads of neuronal survival and cell death. They play important
roles in cellular bioenergetics, control intracellular Ca2+ homeostasis, and participate in key …

Ischemic stroke is still a serious threat to human life and health, but there are few therapeutic
options available to treat stroke because of limited blood-brain penetration. The …

Diabetic peripheral neuropathy (DPN) is a major complication of diabetes mellitus with a
high incidence. Oxidative stress, which is a crucial pathophysiological pathway of DPN, has …

Abstract Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is widely known as a
glycolytic enzyme. Nevertheless, various functions of GAPDH have been found that are …

Glycolytic glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a multifunctional protein
that also mediates cell death under oxidative stress. We reported previously that the active …

Cerebrovascular diseases (CBD) are one of the most dangerous complications of
atherosclerosis. The clinical consequences of CBD deeply impact quality of life and the …

Neurodegeneration is a salient feature of chronic refractory brain disorders like Alzheimer's,
Parkinson's, Huntington's, amyotropic lateral sclerosis and acute conditions like cerebral …

Several studies indicate that mitochondrial uncoupling protein 2 (UCP2) plays a pivotal role
in cancer development by decreasing reactive oxygen species (ROS) produced by …

Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive and devastating
human malignancies. In about 70% of PDACs the tumor suppressor gene TP53 is mutated …