The CNS critically relies on the formation and proper function of its vasculature during
development, adult homeostasis and disease. Angiogenesis—the formation of new blood …

The cerebrovasculature is essential to brain health and is tasked with ensuring adequate
delivery of oxygen and metabolic precursors to ensure normal neurologic function. This is …

To elucidate the pathogenesis of vein of Galen malformations (VOGMs), the most common
and most severe of congenital brain arteriovenous malformations, we performed an …

Patients with brain arteriovenous malformation (bAVM) are at risk of intracranial hemorrhage
(ICH). Overall, bAVM accounts for 25% of hemorrhagic strokes in adults< 50 years of age …

Port-wine birthmarks (PWBs) are caused by somatic, mosaic mutations in the G protein
guanine nucleotide binding protein alpha subunit q (GNAQ) and are characterized by the …

Background and Objectives Ras–mitogen-activated protein kinase (MAPK) signaling
abnormalities occur in most brain arteriovenous malformations (bAVMs). No means exist to …

A variety of pathogenic mechanisms have been described in the formation, maturation, and
rupture of brain arteriovenous malformations (bAVMs). While the understanding of bAVMs …

The spleen is critical for immunity. It is the largest immune organ and immune center in the
peripheral system. While the relationship between behavior and immunity has been …

Background Longitudinal mouse models of brain arteriovenous malformations (AVMs) are
crucial for developing novel therapeutics and pathobiological mechanism discovery …

Abstract Background Brain arteriovenous malformations (AVMs) are rare, potentially
devastating cerebrovascular lesions that can occur in both children and adults. AVMs are …