Phosphoinositides are signalling lipids derived from phosphatidylinositol, a ubiquitous
phospholipid in the cytoplasmic leaflet of eukaryotic membranes. Initially discovered for their …

Autophagy is a major intracellular degradation system that derives its degradative abilities
from the lysosome. The most well-studied form of autophagy is macroautophagy, which …

Neuronal cell death occurs extensively during development and pathology, where it is
especially important because of the limited capacity of adult neurons to proliferate or be …

Macroautophagy is a conserved catabolic process observed in all eukaryotic cells, during
which selected cellular components are transported to and broken down within lysosomes …

Macroautophagy involves the sequestration of cytoplasmic contents in a double-membrane
autophagosome and their delivery to lysosomes for degradation. In multicellular organisms …

Macroautophagy (autophagy) is a highly conserved intracellular degradation system that is
essential for homeostasis in eukaryotic cells. Due to the wide variety of the cytoplasmic …

Over the past two decades, the molecular machinery that underlies autophagic responses
has been characterized with ever increasing precision in multiple model organisms …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Macroautophagy/autophagy refers to the engulfment of cellular contents selected for
lysosomal degradation. The final step in autophagy is the fusion of autophagosome with the …

Lysosomes are key cellular catabolic centers that also perform fundamental metabolic,
signaling and quality control functions. Lysosomes are not static and they respond …