Phosphoinositides as membrane organizers
Phosphoinositides are signalling lipids derived from phosphatidylinositol, a ubiquitous
phospholipid in the cytoplasmic leaflet of eukaryotic membranes. Initially discovered for their …
phospholipid in the cytoplasmic leaflet of eukaryotic membranes. Initially discovered for their …
Lysosome biology in autophagy
WWY Yim, N Mizushima - Cell discovery, 2020 - nature.com
Autophagy is a major intracellular degradation system that derives its degradative abilities
from the lysosome. The most well-studied form of autophagy is macroautophagy, which …
from the lysosome. The most well-studied form of autophagy is macroautophagy, which …
Neuronal cell death
M Fricker, AM Tolkovsky, V Borutaite… - Physiological …, 2018 - journals.physiology.org
Neuronal cell death occurs extensively during development and pathology, where it is
especially important because of the limited capacity of adult neurons to proliferate or be …
especially important because of the limited capacity of adult neurons to proliferate or be …
[HTML][HTML] Autophagosome-lysosome fusion
Macroautophagy is a conserved catabolic process observed in all eukaryotic cells, during
which selected cellular components are transported to and broken down within lysosomes …
which selected cellular components are transported to and broken down within lysosomes …
Autophagosome maturation: an epic journey from the ER to lysosomes
YG Zhao, H Zhang - Journal of Cell Biology, 2019 - rupress.org
Macroautophagy involves the sequestration of cytoplasmic contents in a double-membrane
autophagosome and their delivery to lysosomes for degradation. In multicellular organisms …
autophagosome and their delivery to lysosomes for degradation. In multicellular organisms …
New insights into autophagosome–lysosome fusion
S Nakamura, T Yoshimori - Journal of cell science, 2017 - journals.biologists.com
Macroautophagy (autophagy) is a highly conserved intracellular degradation system that is
essential for homeostasis in eukaryotic cells. Due to the wide variety of the cytoplasmic …
essential for homeostasis in eukaryotic cells. Due to the wide variety of the cytoplasmic …
Molecular definitions of autophagy and related processes
Over the past two decades, the molecular machinery that underlies autophagic responses
has been characterized with ever increasing precision in multiple model organisms …
has been characterized with ever increasing precision in multiple model organisms …
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
DJ Klionsky, AK Abdel-Aziz, S Abdelfatah, M Abdellatif… - autophagy, 2021 - Taylor & Francis
In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …
Since then, this topic has received increasing attention, and many scientists have entered …
New insights regarding SNARE proteins in autophagosome-lysosome fusion
X Tian, J Teng, J Chen - Autophagy, 2021 - Taylor & Francis
Macroautophagy/autophagy refers to the engulfment of cellular contents selected for
lysosomal degradation. The final step in autophagy is the fusion of autophagosome with the …
lysosomal degradation. The final step in autophagy is the fusion of autophagosome with the …
Lysosomal size matters
Lysosomes are key cellular catabolic centers that also perform fundamental metabolic,
signaling and quality control functions. Lysosomes are not static and they respond …
signaling and quality control functions. Lysosomes are not static and they respond …