Systemic effects of smoking
DG Yanbaeva, MA Dentener, EC Creutzberg… - Chest, 2007 - Elsevier
Smoking is one of the major lifestyle factors influencing the health of human beings. Life-
long cigarette smokers have a higher prevalence of common diseases such as …
long cigarette smokers have a higher prevalence of common diseases such as …
New markers of inflammation and endothelial cell activation: Part I
PE Szmitko, CH Wang, RD Weisel, JR De Almeida… - Circulation, 2003 - Am Heart Assoc
and by CD40/CD40 ligand (CD40L and CD154) interactions. 18–22 Once adherent, the
monocytes transmigrate into the tunica intima, the innermost layer of the arterial wall …
monocytes transmigrate into the tunica intima, the innermost layer of the arterial wall …
Statin therapy and autoimmune disease: from protein prenylation to immunomodulation
Statins have been prescribed extensively for their cholesterol-lowering properties and
efficacy in cardiovascular disease. However, compelling evidence now exists that statins …
efficacy in cardiovascular disease. However, compelling evidence now exists that statins …
CD40/CD154 interactions at the interface of tolerance and immunity
SA Quezada, LZ Jarvinen, EF Lind… - Annu. Rev. Immunol …, 2004 - annualreviews.org
Development of the acquired immune response is dependent on the signaling of CD40 by
its ligand, CD154. These molecules govern both the magnitude and quality of humoral-and …
its ligand, CD154. These molecules govern both the magnitude and quality of humoral-and …
Inflammation, immunity, and HMG-CoA reductase inhibitors: statins as antiinflammatory agents?
U Schönbeck, P Libby - Circulation, 2004 - Am Heart Assoc
According to traditional thinking, atherosclerosis results from passive lipid deposition in the
vascular wall. Thus, therapies predominantly targeted lipid metabolism. The contemporary …
vascular wall. Thus, therapies predominantly targeted lipid metabolism. The contemporary …
The CD40/CD40 ligand system: linking inflammation with atherothrombosis
C Antoniades, C Bakogiannis, D Tousoulis… - Journal of the American …, 2009 - jacc.org
The role of CD40/CD40 ligand (CD40L) in atherothrombosis is now widely accepted.
However, the exact mechanisms linking the CD40/CD40L system and the soluble form of …
However, the exact mechanisms linking the CD40/CD40L system and the soluble form of …
Biomarkers of atherosclerotic plaque instability and rupture
W Koenig, N Khuseyinova - Arteriosclerosis, thrombosis, and …, 2007 - Am Heart Assoc
Basic research over the last two decades has identified a large number of molecules
pertinent to the atherosclerotic process, which have clearly improved our understanding of …
pertinent to the atherosclerotic process, which have clearly improved our understanding of …
Stimulation of cannabinoid receptor 2 (CB2) suppresses microglial activation
Background Activated microglial cells have been implicated in a number of
neurodegenerative disorders, including Alzheimer's disease (AD), multiple sclerosis (MS) …
neurodegenerative disorders, including Alzheimer's disease (AD), multiple sclerosis (MS) …
Soluble CD40L: risk prediction after acute coronary syndromes
N Varo, JA de Lemos, P Libby, DA Morrow… - Circulation, 2003 - Am Heart Assoc
Background—Elevated plasma concentrations of soluble CD40 ligand (sCD40L) indicate
increased risk for future cardiovascular events in apparently healthy women. This study …
increased risk for future cardiovascular events in apparently healthy women. This study …
The potential relevance of the multiple lipid-independent (pleiotropic) effects of statins in the management of acute coronary syndromes
Emerging data suggest that acute presentations of coronary artery disease may involve a
complex interplay between the vessel wall, inflammatory cells, and the coagulation cascade …
complex interplay between the vessel wall, inflammatory cells, and the coagulation cascade …