Currently, the chemistry of organofluorine compounds is a leading and rapidly developing
area of organic chemistry. Fluorine present in a molecule largely determines its specific …

Introduction Indolizines are structural isomers with indoles. Although several indole-based
commercial drugs are available in the market, none of the indolizine-based drugs are …

Herein, we describe the synthesis of 5-fluoro-dihydroindolizines via dual C–F bond
cleavage in a trifluoromethyl group. The photocatalytic defluorinative coupling of pyrrole-2 …

A new highly efficient method for the synthesis of 2-fluoro-2-nitrostyrenes was described.
Radical nitration of readily available 2-bromo-2-fluorostyrenes with Fe (NO3) 3· 9H2O …

A new metal-free method for the rapid, productive, and scalable preparation of 3-
trifluoromethyl pyrroles has been developed. It is based on the electrophilic nature of the …

A simple base-mediated tandem SN2′/SNV reaction of the readily available α-
trifluoromethyl-α, β-unsaturated carbonyl compounds with N-tosylated 2-aminomalonates …

A one-pot, three-component cascade reaction between pyridine, α-acylmethylbromide, and
maleic anhydride leading to direct access of 1-bromoindolizines in high yields has been …

The reaction of α-CF3-β-(2-nitroaryl) enamines with benzaldehydes led to nitro-substituted
α, β-diaryl-CF3-enones in high yield. Subsequent reduction of the nitro-group to the amino …

In this study, common naturally occurring organic acids, namely oxalic, malonic, succinic,
tartaric and citric acid (as safe, inexpensive, and biodegradable organocatalysts), have been …

The reaction of pyridines with trifluoroacetylated acetylenes was investigated. It was found
that the reaction of various pyridines with two molecules of CF3CO-acetylenes proceeds …