Heat shock proteins (HSPs) constitute a large family of proteins involved in protein folding
and maturation whose expression is induced by heat shock or other stressors. The major …

Heat shock proteins (HSPs) are a large family of chaperones that are involved in protein
folding and maturation of a variety of “client” proteins protecting them from degradation …

Mitochondria are essential for tumor growth and progression. However, the heavy demand
for mitochondrial activity in cancer leads to increased production of mitochondrial reactive …

The intestinal epithelium is a multicellular interface in close proximity to a dense microbial
milieu that is completely renewed every 3–5 days. Pluripotent stem cells reside at the crypt …

Fitness of cells is dependent on protein homeostasis which is maintained by cooperative
activities of protein chaperones and proteolytic machinery. Upon encountering protein …

Heat shock proteins (HSPs) are an evolutionary family of proteins that act as molecular
chaperones. According to their size they have been classified into the following families; …

An understanding of the process by which tumor cells destroy the basement membrane of
the surface epithelium, invade, and metastasize is essential to the development of novel …

Mitochondrial unfolded protein response (UPR mt) is a mitochondria stress response, which
the transcriptional activation programs of mitochondrial chaperone proteins and proteases …

Epithelial-mesenchymal transition (EMT) is important for organ development, metastasis,
cancer stemness, and organ fibrosis. Molecular mechanisms to coordinately regulate …

Lung cancer is the leading cause of cancer-related deaths worldwide, with non-small cell
lung cancer (NSCLC) being the predominant histological subtype. Despite the emergence of …