Obesity and its complications have become a prominent global public health problem that
severely threatens human health. Melatonin, originally known as an effective antioxidant, is …

Melatonin is an old and ubiquitous molecule in nature showing multiple mechanisms of
action and functions in practically every living organism. In mammals, pineal melatonin …

Pyroptosis is a proinflammatory form of cell death that is associated with pathogenesis of
many chronic inflammatory diseases. Melatonin is substantially reported to possess anti …

Melatonin is a highly evolutionary conserved endogenous molecule that is mainly produced
by the pineal gland, but also by other nonendocrine organs, of most mammals including …

The classic theories of aging such as the free radical theory, including its mitochondria‐
related versions, have largely focused on a few specific processes of senescence …

A worldwide increase in the incidence of obesity indicates the unsuccessful battle against
this disorder. Obesity and the associated health problems urgently require effective …

Obesity is associated with macrophage infiltration and metabolic inflammation, both of which
promote metabolic disease progression. Melatonin is reported to possess anti‐inflammatory …

Lipid generates reactive oxygen species (ROS) in consequence to mitochondrial fission
followed by inflammation in propagating hepatic fibrosis. The interaction of SIRT …

Introduction Melatonin has been studied in headache disorders. Amitriptyline is efficacious
for migraine prevention, but its unfavourable side effect profile limits its use. Methods A …

Obesity and its medical complications represent a significant problem throughout the world.
In recent decades, mechanisms underlying the progression of obesity have been intensively …